London Daily

Focus on the big picture.
Sunday, Jul 06, 2025

UK virus variant has developed concerning new mutation in small number of cases

UK virus variant has developed concerning new mutation in small number of cases

The UK variant of the coronavirus has developed a new, concerning mutation in a small number of cases, which scientists said makes it similar to the South African and Brazilian variants and could reduce the efficacy of vaccines.
The emergence of the mutation to the variant first discovered in Britain highlights how complicated exiting COVID-19 lockdown will be even once vaccines are rolled out.

Public Health England said there had been 11 reports of the UK variant which feature the E484K mutation, mostly in south-west England.

The E484K mutation, which occurs on the spike protein of the virus, is the same change as has been seen in the South African and Brazilian variants that have caused international concern.

“PHE is monitoring the situation closely and all necessary public health interventions are being undertaken, including enhanced contact tracing and control measures,” a PHE spokesman said.

Several laboratory studies have found that vaccines and antibody therapy are less effective against the South African variant.

By contrast, early evidence showed that vaccines worked just as well against the UK variant, which originally did not have the E484K mutation.

Health minister Matt Hancock said it was too early to tell the impact of variants on vaccines, but mutations of concern had been reported in Bristol and Liverpool.

“We must continue to act with caution, not least because of the renewed challenges posed by new variants of the coronavirus,” he told lawmakers.

Calum Semple, who is part of a panel that advises the British government, told BBC radio that E484K was the “mutation of most concern”, and had “occurred spontaneously” in the UK variant.

The name E484K, in layman’s terms, is like map coordinates. The number 484 is the exact location of the mutation, the letter E is the amino acid that it was originally and the letter K is the amino acid that it has mutated to.

Concern over the South African variant, with its E484K mutation, has already prompted authorities in England to begin a door-to-door mass testing drive in areas where cases of the variant have been found in people with no link to South Africa, while mandatory quarantine in hotels for arrivals from South Africa is yet to come into force.

Though the number of reported cases of the UK variant with the concerning mutation are small, scientists said that it demonstrated how Britain’s high prevalence of cases meant that it was not enough simply to prevent new variants being imported.

“This report would seem to suggest that under conditions of very high levels of virus replication even the most stringent of border controls, although they may delay spread, are unlikely to prevent the appearance of new variants,” said Jonathan Stoye, virologist at The Francis Crick Institute.
Newsletter

Related Articles

0:00
0:00
Close
U.S. Enacts Sweeping Tax and Spending Legislation Amid Trade Policy Shifts
Football Mourns as Diogo Jota and Brother André Silva Laid to Rest in Portugal
Elon Musk Founds a Party Following a Poll on X: "You Wanted It – You Got It!"
London Stock Exchange Faces Historic Low in Initial Public Offerings
A new online platform has emerged in the United Kingdom, specifically targeting Muslim men seeking virgin brides
Trump Celebrates Independence Day with B-2 Flyover and Signs Controversial Legislation
Boris Johnson Urges Conservatives to Ignore Farage
SNP Ordered to Update Single-Sex Space Guidance Within Days
Starmer Set to Reject Calls for Wealth Taxes
Stolen Century-Old Rolls-Royce Recovered After Hotel Theft
Macron Presses Starmer to Recognise Palestinian State
Labour Delayed Palestine Action Ban Over Riot Concerns
Swinney’s Tax Comments ‘Offensive to Scots’, Say Tories
High Street Retailers to Enforce Bans on Serial Shoplifters
Music Banned by Henry VIII to Be Performed After 500 Years
Steve Coogan Says Working Class Is Being ‘Ethnically Cleansed’
Home Office Admits Uncertainty Over Visa Overstayer Numbers
JD Vance Questions Mandelson Over Reform Party’s Rising Popularity
Macron to Receive Windsor Carriage Ride in Royal Gesture
Labour Accused of ‘Hammering’ Scots During First Year in Power
BBC Head of Music Stood Down Amid Bob Vylan Controversy
Corbyn Eyes Hard-Left Challenge to Starmer’s Leadership
London Tube Trains Suspended After Major Fire Erupts Nearby
Richard Kemp: I Felt Safer in Israel Under Attack Than in the UK
Cyclist Says Police Cited Human Rights Act for Riding No-Handed
China’s Central Bank Consults European Peers on Low-Rate Strategies
AI Raises Alarms Over Long-Term Job Security
Saudi Arabia Maintains Ties with Iran Despite Israel Conflict
Musk Battles to Protect Tesla Amid Trump Policy Threats
Air France-KLM Acquires Majority Stake in Scandinavian Airlines
UK Educators Sound Alarm on Declining Child Literacy
Shein Fined €40 Million in France Over Misleading Discounts
Brazil’s Lula Visits Kirchner During Argentina House Arrest
Trump Scores Legislative Win as House Passes Tax Reform Bill
Keir Starmer Faces Criticism After Rocky First Year in Power
DJI Launches Heavy-Duty Coaxial Quadcopter with 80 kg Lift Capacity
U.S. Senate Approves Major Legislation Dubbed the 'Big Beautiful Bill'
Largest Healthcare Fraud Takedown in U.S. History Announced by DOJ
Poland Implements Border Checks Amid Growing Migration Tensions
Political Dispute Escalates Between Trump and Musk
Emirates Airline Expands Market Share with New $20 Million Campaign
Amazon Reaches Milestone with Deployment of One Millionth Robot
US Senate Votes to Remove AI Regulation Moratorium from Domestic Policy Bill
Yulia Putintseva Calls for Spectator Ejection at Wimbledon Over Safety Concerns
Jury Deliberations in Diddy Trial Yield Partial Verdict in Serious Criminal Charges
House Oversight Committee Subpoenas Former Jill Biden Aide Amid Investigation into Alleged Concealment of President Biden's Cognitive Health
King Charles Plans Significant Role for Prince Harry in Coronation
Two Chinese Nationals Arrested for Espionage Activities Against U.S. Navy
Amazon Reaches Major Automation Milestone with Over One Million Robots
Extreme Heat Wave Sweeps Across Europe, Hitting Record Temperatures
×