London Daily

Focus on the big picture.
Sunday, Mar 22, 2026

Explainer: Could The Omicron Variant Bring Milder Illness?

Explainer: Could The Omicron Variant Bring Milder Illness?

Scientists race to understand the full consequences of Omicron, some are also asking whether this new version of coronavirus might cause milder illness than its predecessors.

The Omicron variant, spreading now in southern Africa and detected in over 30 other countries, has prompted fears it could significantly undermine the effectiveness of vaccines against COVID-19.

Yet as scientists race to understand the full consequences of Omicron, some are also asking whether this new version of coronavirus might cause milder illness than its predecessors. While they caution that it is far too early to draw conclusions, here is what is known so far:

What Do The Data Show?


Evidence from initial cases of the new variant is limited.

Among 70 cases reported in Europe that included information on disease severity, half of the patients had no symptoms and half had mild symptoms, according to a report on Thursday by the European Centre for Disease Prevention and Control.

There were no cases of severe disease, hospitalization, or death. However, the European agency said it would require data on hundreds of cases to accurately assess disease complications, estimating that could take several weeks. In addition, most cases detected in Europe so far have been in younger people who were fully vaccinated, making them less likely to suffer severe illness.

In South Africa, where the daily number of reported COVID-19 cases doubled on Wednesday to 8,561, symptoms for reinfected patients and those infected after vaccination appear to be mild.

"Some evidence from South Africa suggests that it may actually cause more mild illness but. I caution you that a lot of the patients South Africa initially were among young university students," Dr. Carlos Del Rio, an infectious diseases expert at Emory University in Atlanta, said on Thursday during an online briefing from the Infectious Diseases Society of America.

Is Omicron A 'Less Fit' Version Of Coronavirus?

While data on real world infections continues to emerge, scientists are conducting laboratory studies to decipher Omicron. The variant has about 50 mutations not seen in combination before, including more than 30 mutations on the spike protein the coronavirus uses to attach to human cells. Vaccines in current use target that spike protein.

"Typically when viruses accumulate a lot of mutations they lose some fitness," said Dr. John Wherry, director of the Penn Institute for Immunology in Philadelphia. Certain Omicron mutations may impair the ability of the virus to cleave, changing the behavior of the spike protein, he said.

Some scientists have theorized Omicron may have developed over a period of months in an immunocompromised individual, such as an HIV patient in southern Africa. If so, "the virus adapted not to kill that host," Wherry said.

There are competing theories that the latest variant evolved from an animal host.

Will Omicron Become The Dominant Variant?


The other central question surrounding Omicron is whether it will overtake the Delta variant, which still accounts for the overwhelming majority of known infections worldwide. If Omicron does become dominant, but causes milder illness, it could mark a turning point toward the virus eventually becoming a seasonal threat, like influenza, said Sumit Chanda, an infectious disease researcher at the Scripps Research Department of Immunology and Microbiology in San Diego.

The European Union's public health agency said on Thursday the Omicron variant could be responsible for more than half of all COVID-19 infections in Europe within a few months.

While the research into Omicron is underway, disease experts say people must remain vigilant against the coronavirus by getting either initial vaccinations or booster shots, as well as wearing masks in indoor or crowded settings, ventilating rooms and washing hands.

Newsletter

Related Articles

0:00
0:00
Close
Duchess of Sussex Secures ‘As Ever’ Trademark Rights in Australia Ahead of High-Profile Visit
UK Reaffirms Security as Officials Reject Claims of Immediate Iranian Missile Threat
Rising Middle East Tensions Spark ‘Trumpflation’ Debate Over Impact on UK Households
UK Minister Says No Evidence Iran Can Strike Europe Despite Heightened Warnings
British-Iranians Voice Safety Concerns to Authorities as Regional Conflict Intensifies
Confirmed Meningitis Cases Linked to Kent Outbreak Revised Down to Twenty
UK Government Sees No Evidence Iran Can Strike London Amid Rising Regional Tensions
Debate Grows Over Recognition of Indigenous Cultural Icons in the United Kingdom
Iran Missile Launch Toward Diego Garcia Raises Questions After Failed Strike on US–UK Base
Donald Trump Amplifies Viral Satirical Clip Highlighting UK–US Political Dynamics
UK Satirical Show Draws Attention with Sketch Referencing Trump and Prince Andrew
Meghan Markle’s Possible UK Return Sparks Renewed Attention on Sussex Role
Starmer Convenes Urgent Talks on Cost-of-Living Pressures Linked to Iran Conflict
Starmer Convenes Urgent Talks on Cost-of-Living Pressures Linked to Iran Conflict
UK Investors Eye Bargain Shares Ahead of ISA Deadline Amid Market Volatility
UK Investors Eye Bargain Shares Ahead of ISA Deadline Amid Market Volatility
Northern Lights Expected Over UK Skies Tonight Amid Strong Solar Activity
UK Condemns Iran Missile Strike and Warns Against Threats to British Personnel
UK Warns of Global Flight Disruptions as Iran Conflict Escalates Under Trump’s Leadership
UK Condemns Iran After Missile Strike Targets Strategic Diego Garcia Base
Deadly Meningitis Outbreak in UK Reinforces Urgency of Vaccination Campaigns
Iran Launches Long-Range Missile Strike on Remote US-UK Base, Signaling Expanded Reach
Iran Launches Long-Range Missile Strike on Remote US-UK Base, Signaling Expanded Reach
UK Rules Out Cyprus Base Role in Joint US Self-Defence Framework
UK Ends Hereditary Peerage Rights in Parliament in Historic Constitutional Reform
Lord Walney Warns of Expanding Iranian Influence Networks Within the United Kingdom
Iranian National Among Two Arrested After Attempt to Access UK Nuclear Submarine Base
Deregulation, Artificial Intelligence, and Fraud Laws Reshape UK Financial Services Landscape
UK Considers Lower Speed Limits to Reduce Fuel Use Amid Escalating Energy Crisis
UK Borrowing Costs Surge to Post-Crisis High as Markets React to Inflation and War Risks
UK Government Prepares Emergency Economic Measures as Iran Conflict Fuels Financial Risks
Meningitis B Outbreak in the UK Raises Urgent Health Warnings as Cases Surge
Iran Issues Stark Warning to Britain Over US Base Access Amid Expanding Conflict
United Kingdom Authorizes US Strikes from British Bases as Iran Threatens Key Shipping Routes
Reform UK Suspends Scottish Candidate Following Financial Misconduct Allegations
Apple issues an unusual warning: this is how your iPhone can be hacked without you doing anything
UK and Nigeria Reach Agreement to Accelerate Return of Irregular Migrants
UK Sets New Aid Priorities Following Significant Budget Reductions
Cyprus President Urges Open Dialogue Over Future of British Sovereign Base Areas
Cyprus President Urges Open Dialogue Over Future of British Sovereign Base Areas
UK Plans 50% Steel Tariffs in Bold Move to Protect Domestic Industry
Iran Conflict Sends Shockwaves Through UK Economy as Energy Costs and Trade Risks Surge
UK Health Officials Warn Kent Meningitis Outbreak Still Active as Cases Continue to Rise
UK Climate Progress Faces Scrutiny Over Reliance on Carbon Accounting Methods
UK Deploys Advisers to United States to Shape Plan for Reopening Strait of Hormuz
Amazon Bets on AI-Driven Alexa Upgrade to Revive UK Smart Speaker Market
UK Abortion Law Changes Spark Strong Response from Church Leaders and Pro-Life Advocates
UK Abortion Law Changes Spark Strong Response from Church Leaders and Pro-Life Advocates
GB News Faces Regulatory Complaints Over On-Air Remarks on ‘Genocide’ Claims
UK Signals Expanded Support for Gulf Allies as Iranian Attacks Intensify Regional Threats
×