London Daily

Focus on the big picture.
Friday, Oct 16, 2026

Explainer: Could The Omicron Variant Bring Milder Illness?

Explainer: Could The Omicron Variant Bring Milder Illness?

Scientists race to understand the full consequences of Omicron, some are also asking whether this new version of coronavirus might cause milder illness than its predecessors.

The Omicron variant, spreading now in southern Africa and detected in over 30 other countries, has prompted fears it could significantly undermine the effectiveness of vaccines against COVID-19.

Yet as scientists race to understand the full consequences of Omicron, some are also asking whether this new version of coronavirus might cause milder illness than its predecessors. While they caution that it is far too early to draw conclusions, here is what is known so far:

What Do The Data Show?


Evidence from initial cases of the new variant is limited.

Among 70 cases reported in Europe that included information on disease severity, half of the patients had no symptoms and half had mild symptoms, according to a report on Thursday by the European Centre for Disease Prevention and Control.

There were no cases of severe disease, hospitalization, or death. However, the European agency said it would require data on hundreds of cases to accurately assess disease complications, estimating that could take several weeks. In addition, most cases detected in Europe so far have been in younger people who were fully vaccinated, making them less likely to suffer severe illness.

In South Africa, where the daily number of reported COVID-19 cases doubled on Wednesday to 8,561, symptoms for reinfected patients and those infected after vaccination appear to be mild.

"Some evidence from South Africa suggests that it may actually cause more mild illness but. I caution you that a lot of the patients South Africa initially were among young university students," Dr. Carlos Del Rio, an infectious diseases expert at Emory University in Atlanta, said on Thursday during an online briefing from the Infectious Diseases Society of America.

Is Omicron A 'Less Fit' Version Of Coronavirus?

While data on real world infections continues to emerge, scientists are conducting laboratory studies to decipher Omicron. The variant has about 50 mutations not seen in combination before, including more than 30 mutations on the spike protein the coronavirus uses to attach to human cells. Vaccines in current use target that spike protein.

"Typically when viruses accumulate a lot of mutations they lose some fitness," said Dr. John Wherry, director of the Penn Institute for Immunology in Philadelphia. Certain Omicron mutations may impair the ability of the virus to cleave, changing the behavior of the spike protein, he said.

Some scientists have theorized Omicron may have developed over a period of months in an immunocompromised individual, such as an HIV patient in southern Africa. If so, "the virus adapted not to kill that host," Wherry said.

There are competing theories that the latest variant evolved from an animal host.

Will Omicron Become The Dominant Variant?


The other central question surrounding Omicron is whether it will overtake the Delta variant, which still accounts for the overwhelming majority of known infections worldwide. If Omicron does become dominant, but causes milder illness, it could mark a turning point toward the virus eventually becoming a seasonal threat, like influenza, said Sumit Chanda, an infectious disease researcher at the Scripps Research Department of Immunology and Microbiology in San Diego.

The European Union's public health agency said on Thursday the Omicron variant could be responsible for more than half of all COVID-19 infections in Europe within a few months.

While the research into Omicron is underway, disease experts say people must remain vigilant against the coronavirus by getting either initial vaccinations or booster shots, as well as wearing masks in indoor or crowded settings, ventilating rooms and washing hands.

Newsletter

Related Articles

0:00
0:00
Close
MI5 Warns of Growing Russian Sabotage and Espionage Threats Across Britain
UK Prime Minister Andy Burnham Plans Brussels Talks to Renegotiate Post-Brexit Trade Deal
MI5 Warns of Rising Russian and Iranian Sabotage Threats to British Military Facilities
UK Prime Minister Andy Burnham Pledges Closer EU Ties as MI5 Reveals Russian Brexit Interference
UK Orders Security Review Following Reported Killing of Former Politician Ann Widdecombe
UK Prime Minister Andy Burnham Meets German Chancellor Merz to Strengthen European Security Ties
Nearly 100,000 NHS Patients Treated in Hospital Corridors as England Braces for Winter Pressures
UK Government Rejects US-Russia Diesel Agreement and Reaffirms Sanctions Against Moscow
UK and Germany Agree to Deepen Security and Economic Cooperation Following Berlin Talks
British Prime Minister Burnham Pledges Closer EU Ties During Visit to Germany
UK Announces New Sanctions on 17 Russia-Linked Entities During Foreign Secretary's Ukraine Visit
UK and Germany Finalize Kensington Treaty to Strengthen Defense and Technology Cooperation
Britain Maintains Diplomatic Mission in East Jerusalem Despite Israeli Closure Deadline
English Councils Push Government to Rethink Proposed Funding Cuts
Scottish Homebuilding Falls to Lowest Level in 11 Years
BBC Chief Matt Brittin Defends Restructuring as Staff Challenge Job Cuts
UK Finance Warns High Energy Costs and Bond Yields Are Complicating Fiscal Outlook
UK Adopts All 44 Recommendations on Regulating AI in Healthcare
Chancellor John Healey Prepares Autumn Budget as Borrowing Costs Strain Public Finances
UK Investigators See Strong Indications of Iranian Link After RAF Fairford Security Operation
Laura Trott Pledges Tighter Controls on Political Activism in UK Classrooms
Welsh Ministers Launch Long-Term Review of North Wales and Anglesey Crossings
Welsh Government Orders 18-Month Study of Road Solutions Around Newport
Reform UK MP Sarah Pochin Faces Scrutiny Over £800,000 Second Home Purchase
British Households Grow More Concerned About Fuel and Energy Prices
NHS Leaders Warn of Rising Winter Pressure on Emergency Departments
Kemi Badenoch Proposes £2.3 Billion Employer National Insurance Cut for Young Workers
Middle East Conflict Could Erase UK Fiscal Headroom, Economists Warn
Manchester City Found Guilty of Multiple Premier League Financial Rule Breaches
UK Security Services Find Strong Indications of Iranian Role in RAF Fairford Incident
Costa Coffee Returns to Operating Profit on Iced Drinks and Menu Changes
Asos Warns Customers After Unauthorized Access to Retail App and Data
Kemi Badenoch Puts Growth and Deregulation at Center of Conservative Conference
Campaigners Warn of Deepening Social Care Crisis for Disabled Adults
Study Finds Rising Early-Onset Cancer Rates Among Adults Under 50 in Britain
UK Coach Operators Warn High Diesel Prices Could Force Route Cuts
FCA Opens Independent Review Into Handling of Epstein-Linked Whistleblower Case
Argentina Vows to Block Falkland Islands Offshore Oil Development
UK Chancellor Prepares Fiscal Measures and Welfare Reforms Ahead of Autumn Budget
Sainsbury’s and Morrisons Explore Potential Multi-Billion-Pound Merger
UK Weighs Tariffs on Chinese Electric Vehicles to Align With European Union
UK Threatens Diplomatic Expulsions Over Planned Closure of East Jerusalem Consulate
UK Energy Price Cap Hits Three-Year High as Middle East Conflict Raises Costs
Seventh Arrest Made in Suspected Terror Plot at RAF Fairford
Systemic Education Collapse Sparks Mass Student Uprisings in France
Green Party Faces Backlash Over Resolution Equating Zionism With Racism
Conservatives Debate Scrapping Environmental Rules for New Homes
Cornwall Insight Warns UK Energy Bills Could Approach £2,000 This Winter
UK Coach Operators Warn of Service Cuts as Diesel Prices Exceed £2
Scottish Parliament Approves £68 Billion Budget With New Tax and Property Measures
×