London Daily

Focus on the big picture.
Sunday, Jul 12, 2026

A Guide to the Skincare Ingredients You Should Never Mix

A Guide to the Skincare Ingredients You Should Never Mix

We all know oil and water don't mix-but did you know Vitamin C and retinol together are a literal recipe for disaster?

So, you’re finally starting to create a skincare routine-or maybe you’re revamping the one you’ve been following for years. Regardless, when choosing new skincare products, it’s imperative to know which ones will mix and layer well together. Based on your skin type, it might be tricky to figure out which products complement each other the best, and you might go through some trial-and-error. Here, L’OFFICIEL guides you on your new skincare routine with a list of skincare ingredients that you should never mix together.

Alpha Hydroxy Acids + Vitamin C + Retinol


According to the dermatologist, mixing these actives can cause hyper-reactivity of the skin, excessive exfoliation and increased propensity for blemishes, especially if a good sunscreen is not used.

Still, there are products that use these ingredients in combination. Would that be a problem? According to Thatiana, no. “They are formulated to work together, and the concentrations are adjusted so that they don't cause problems” explains the expert.

"What's not interesting is making product mixtures with these acids that haven't been formulated to work together."



Benzoyl Peroxide + Retinol


When using these ingredients in combination, benzoyl peroxide can negate the effect of Retinol, because it causes the ingredient to oxidize. “If applied together with retinol, which is a vitamin A derivative and acts on the skin, making cell renewal, it increases the chance of peeling and skin sensitization,” explains the dermatologist.



Benzoyl Peroxide + Hydroquinone


Joining hydroquinone with products that contain peroxides can cause negative effects on the skin. This union can result in darkening of the skin in the treated areas, as these ingredients together can cause hypersensitivity, causing erythemia and a slight burning sensation.

However, if this has happened to you, don't worry. Thatiana reveals that this can all be reversed by interrupting the use of these ingredients.



Retinol + Salicylic Acid


These two ingredients have an exfoliating action and, therefore, when used in combination, they can cause irritation and dryness of the skin. According to the dermatologist, when used together they can damage the skin's protective barrier, causing the skin to become dull and dull.



Hydroquinone + Alpha hydroxy acid


At very high concentrations, the use of hydroquinone and high hydroxyoxide can cause skin irritation, redness and peeling. However, used correctly it can be an amazing match!

When asked about the use of these ingredients together, Thatiana reveals that they are both often indicated for lightening blemishes and smoothing the skin.

“Among the benefits of alpha hydroxy acids, glycolic acid is the most famous representative of the AHA group” explains “We can emphasize chemical exfoliation, cell renewal, lightening of blemishes, acne treatment and rejuvenation aid”.



Glycolic Acid + Retinoic Acid


According to the specialist, we should not associate acids such as glycolic and retinoic acid or even Retinol in the skin. This is because, in high concentration, glycolic acid has the function of chemical exfoliation, and retinoic acid, in addition to causing skin renewal, has a greater role in the synthesis of collagen, making the fibers more elastic and giving more firmness and thickness to the skin.

“But not all skin tolerates retinoic acid, especially in the highest concentrations of creams manipulated with a doctor's prescription. It can cause redness, irritation and peeling,” explains Thatiana. "To have a beautiful, lightened and renewed skin usually only one of these 'stars' can be the main actor".

Newsletter

Related Articles

0:00
0:00
Close
Government Creates Emergency Support Scheme for Financially Struggling Universities
United Kingdom Replaces Traditional Farm Subsidies With Payments Linked to Environmental Performance
National Grid Reports First Week of Electricity Generation Without Fossil Fuels
United Kingdom Financial Regulator Introduces Tougher Capital Rules for Cryptocurrency Exchanges
Belfast Harbour Expands Operations to Attract Investment Through United Kingdom and European Union Market Access
Scottish Government Threatens Legal Challenge Over Westminster Cuts to North Sea Transition Funding
United Kingdom Accelerates Trans-Pennine High-Speed Rail Project Linking Northern Cities
United Kingdom Secures Ten Billion Pound Investment for Cambridge Quantum Computing Campus
Port Talbot Steelworks Wins Support for Green Hydrogen Transition and Protection of Industrial Jobs
United Kingdom Sends Royal Navy Carrier Strike Group to Indo-Pacific as Regional Security Focus Expands
National Health Service Expands Artificial Intelligence Diagnostics Across England to Reduce Screening Backlogs
United Kingdom Launches Fifty Billion Pound Infrastructure Fund to Accelerate Housing and Construction
UK Medical Chiefs Update Health Guidance to Promote Everyday Physical Activity
Office of Communications Keeps Wikipedia Under Review Under UK Online Safety Rules
UK Defence Ministry Expands Deep-Strike Capability Through Precision Missile Programme
Russell Group Universities Warn Funding Cuts Could Damage NHS Workforce Training
UK Parliament Calls for National Emergency Broadcast as Heatwave Conditions Intensify
UK and Netherlands Strengthen Naval Cooperation With New Amphibious Defence Partnership
UK Defence Ministry Joins International Missile Programme With One Hundred and Ninety Million Pound Investment
Bank of England Warns Middle East Conflict and AI Risks Could Pressure UK Economy
UK Government Introduces New Rules to Limit Foreign Influence in Political Donations
UK and France Prepare Naval Mission to Protect Shipping Through Strait of Hormuz
United States Pressures UK to Increase Defence Spending at NATO Summit
Bank of England Warns Artificial Intelligence Investment Boom Could Create Financial Stability Risks
Bank of England Begins Direct Oversight of Critical Technology Providers Supporting UK Finance
Andy Burnham Set to Become UK Prime Minister After Labour Leadership Race Clears Path to Downing Street
Scottish Fishing Industry Calls for Emergency Support Amid Rising Costs
UK Supports Stronger European Response to Russian Actions in Ukraine
Devon and Cornwall Police Release Suspect in Ann Widdecombe Murder Investigation
Scottish MPs Demand More Government Support for Fishing Industry
UK Aviation Sector Faces New Rules as Parliament Reviews Passenger Protection Reforms
King’s College London Disciplines Students Over Pro-Palestine Campus Protests
Ministry of Defence Expands Military Capabilities Through New Precision Strike Investment
United Kingdom Condemns Russian Treatment of Ukrainian Children at International Security Forum
House of Lords Reviews Civil Aviation Bill to Strengthen Passenger Rights and UK Aviation Competitiveness
UK Aerospace and Defence Industries Contribute Nearly Forty-Seven Billion Pounds to Economy
UK Government Advances Consultation on Possible Social Media Ban for Children Under Sixteen
United Kingdom Ratifies Global High Seas Treaty to Protect Marine Biodiversity
United Kingdom Joins United States Precision Strike Missile Programme With One Hundred Ninety Million Pound Investment
UK Senior NHS Doctors Vote for Further Strike Action Over Pay and Contract Disputes
BBC Leadership Resigns After Donald Trump Launches Ten Billion Dollar Defamation Lawsuit
UK Fiscal Watchdog Warns Andy Burnham Government Faces One Hundred Billion Pound Budget Challenge
The AI Invoice Shock: Layoffs Didn't Save Managers Money — They Cost Them More
Concern: Sexually Transmitted Bacterium Among Men Develops Antibiotic Resistance
Following Massive Investor Demand: SK Hynix Raises 26.5 Billion Dollars on Nasdaq
Passenger Partially Pulled Out of Ryanair Jet After Cabin Window Fails Mid-Flight
After Four Years, and Under a Heavy Veil of Secrecy: King Charles Meets His Grandchildren, Harry and Meghan's Children
Cross-Party MPs Call for National Climate Emergency Broadcast
Bayeux Tapestry Arrives in the United Kingdom for Landmark Exhibition
United Kingdom Launches Modern Slavery Prevention Programme in Vietnam
×