London Daily

Focus on the big picture.
Monday, Jul 20, 2026

A Guide to the Skincare Ingredients You Should Never Mix

A Guide to the Skincare Ingredients You Should Never Mix

We all know oil and water don't mix-but did you know Vitamin C and retinol together are a literal recipe for disaster?

So, you’re finally starting to create a skincare routine-or maybe you’re revamping the one you’ve been following for years. Regardless, when choosing new skincare products, it’s imperative to know which ones will mix and layer well together. Based on your skin type, it might be tricky to figure out which products complement each other the best, and you might go through some trial-and-error. Here, L’OFFICIEL guides you on your new skincare routine with a list of skincare ingredients that you should never mix together.

Alpha Hydroxy Acids + Vitamin C + Retinol


According to the dermatologist, mixing these actives can cause hyper-reactivity of the skin, excessive exfoliation and increased propensity for blemishes, especially if a good sunscreen is not used.

Still, there are products that use these ingredients in combination. Would that be a problem? According to Thatiana, no. “They are formulated to work together, and the concentrations are adjusted so that they don't cause problems” explains the expert.

"What's not interesting is making product mixtures with these acids that haven't been formulated to work together."



Benzoyl Peroxide + Retinol


When using these ingredients in combination, benzoyl peroxide can negate the effect of Retinol, because it causes the ingredient to oxidize. “If applied together with retinol, which is a vitamin A derivative and acts on the skin, making cell renewal, it increases the chance of peeling and skin sensitization,” explains the dermatologist.



Benzoyl Peroxide + Hydroquinone


Joining hydroquinone with products that contain peroxides can cause negative effects on the skin. This union can result in darkening of the skin in the treated areas, as these ingredients together can cause hypersensitivity, causing erythemia and a slight burning sensation.

However, if this has happened to you, don't worry. Thatiana reveals that this can all be reversed by interrupting the use of these ingredients.



Retinol + Salicylic Acid


These two ingredients have an exfoliating action and, therefore, when used in combination, they can cause irritation and dryness of the skin. According to the dermatologist, when used together they can damage the skin's protective barrier, causing the skin to become dull and dull.



Hydroquinone + Alpha hydroxy acid


At very high concentrations, the use of hydroquinone and high hydroxyoxide can cause skin irritation, redness and peeling. However, used correctly it can be an amazing match!

When asked about the use of these ingredients together, Thatiana reveals that they are both often indicated for lightening blemishes and smoothing the skin.

“Among the benefits of alpha hydroxy acids, glycolic acid is the most famous representative of the AHA group” explains “We can emphasize chemical exfoliation, cell renewal, lightening of blemishes, acne treatment and rejuvenation aid”.



Glycolic Acid + Retinoic Acid


According to the specialist, we should not associate acids such as glycolic and retinoic acid or even Retinol in the skin. This is because, in high concentration, glycolic acid has the function of chemical exfoliation, and retinoic acid, in addition to causing skin renewal, has a greater role in the synthesis of collagen, making the fibers more elastic and giving more firmness and thickness to the skin.

“But not all skin tolerates retinoic acid, especially in the highest concentrations of creams manipulated with a doctor's prescription. It can cause redness, irritation and peeling,” explains Thatiana. "To have a beautiful, lightened and renewed skin usually only one of these 'stars' can be the main actor".

Newsletter

Related Articles

0:00
0:00
Close
Charlie Sheen’s Daughter: "My Dad Didn’t Buy Me a House, My Breasts Bought It"
Vivienne Westwood Casts Cicciolina, 74, in Its New Autumn Campaign
Dejavu: Germany’s Military Expansion Reshapes Europe’s Strategic Balance With France
Jingye Demands Full Compensation After Britain illegally Nationalized British Steel
London’s Housing Starts Collapse as Planning and Building Costs Stall Development
Morgan Stanley Builds a Wall Street Lead in AI Infrastructure Finance
High Prices Push Coffee Drinkers Toward Whole Beans and Home Brewing
Trump Draws Boos and Podium Scrutiny at Spain’s World Cup Triumph
Brilliant move: Péter Magyar Moves to Nominate Chess Grandmaster Judit Polgár as Hungary’s President
Spain Defeats Argentina in Extra Time to Win Second World Cup
Police Block Cockroach Janta Party’s March to Parliament as Education Protests Intensify
Current AI Seeks to Build an Open Global AI Infrastructure Outside Big Tech Control
Turkey Explores S-400 Transfer to UAE in Bid to Rejoin F-35 Program
Josh Kerr Breaks Twenty-Seven-Year World Mile Record at London Diamond League
Thames Water Crisis Deepens as South East Water Outages Hit Thousands in Kent
EU Ban on Destroying Unsold Clothing Forces British Fashion Brands to Change Operations
UK Government Confirms Existing North Sea Oil and Gas Licences Will Be Honoured
UK Covid Inquiry Finds Nearly Ten Billion Pounds Lost in Pandemic Protective Equipment Procurement
Thames Water Moves Toward Possible Temporary Nationalisation Amid Rescue Plan Dispute
Andy Burnham Cancels One Point Eight Billion Pound Digital ID Programme After Taking Office
UK Government Takes British Steel Into Full Public Ownership to Protect Jobs and Supply Chains
Andy Burnham Becomes UK Prime Minister and Pledges Focus on Living Costs and Public Services
Germany’s Economic Malaise Reopens the Sunday Shopping Debate
Singapore Considers Lower Taxes for Fund Managers as Hong Kong Intensifies Talent Contest
US Retaliates Against Iran After Two American Troops Killed in Jordan
Bank of Asia BVI Enters Court-Supervised Liquidation After Regulators Find It Insolvent
Proposed U.S.-Saudi Nuclear Pact Could Permit Limited Uranium Enrichment Under International Safeguards
Netherlands Declares Water Shortage Emergency After Drought Pushes Rivers to Historic Lows
Why Kentucky Fried Chicken Became KFC—and Why the False Explanations Persist
Iran Claims It Destroyed Bahrain’s Main Artificial Intelligence Center in Missile and Drone Strike
Ukrainian Drones Strike Wildberries Warehouses Deep Inside Russia
Brothers Andrew and Tristan Tate Who Turned "Toxic Masculinity" Into a Brand Arrested in Miami as Britain Seeks Their Extradition
Reported CIA Mission Helped Clear the UAE’s Path to Advanced US AI Chips
Artificial Intelligence Capital Fuels Markets While Governments and Regulators Face Mounting Strategic Tests
China’s Moonshot’s Kimi K3 Narrows the Gap With Anthropic Through Scale, Openness and Lower Cost
Gold and Cash Seizure Puts Indonesia’s Senior Anti-Corruption Prosecutor Under Investigation
The Ledger Will Not Trust on Faith
Bank of England Warns Climate Shocks Could Trigger Sudden Asset Repricing
UK Treasury Places Microsoft, Google, AWS and Oracle Under New Financial Resilience Rules
Scottish Government Faces Pressure Over Delays in Vulnerable Group Background Checks
Crown Prosecution Service Authorises Additional Charges Against Andrew and Tristan Tate
NHS Approves At-Home Cancer Treatments for Rare Blood Disorders
Bank of England Gains Oversight of Major Cloud Providers Supporting UK Financial System
UK Government Plans Major Overhaul of English Local Councils Through New Unitary Authorities
British Steel Nationalisation Dispute Escalates as Chinese Owner Jingye Seeks Compensation
Bank of England Signals Interest Rates Will Stay High as It Warns of Financial Risks From Climate and AI
Trump Administration Pressures Banks to Restrict Financial Access for Undocumented Immigrants
Passenger Bound for Germany Refused to Sit Beside a Woman on a Plane — Then Slapped a Flight Attendant
Ukraine’s Leadership Rift Spills Into the Streets as Protesters Target Army Chief
Ukrainian Drone Barrage Kills Eight and Strikes Russian Logistics Network
×