London Daily

Focus on the big picture.
Tuesday, Jun 23, 2026

A Guide to the Skincare Ingredients You Should Never Mix

A Guide to the Skincare Ingredients You Should Never Mix

We all know oil and water don't mix-but did you know Vitamin C and retinol together are a literal recipe for disaster?

So, you’re finally starting to create a skincare routine-or maybe you’re revamping the one you’ve been following for years. Regardless, when choosing new skincare products, it’s imperative to know which ones will mix and layer well together. Based on your skin type, it might be tricky to figure out which products complement each other the best, and you might go through some trial-and-error. Here, L’OFFICIEL guides you on your new skincare routine with a list of skincare ingredients that you should never mix together.

Alpha Hydroxy Acids + Vitamin C + Retinol


According to the dermatologist, mixing these actives can cause hyper-reactivity of the skin, excessive exfoliation and increased propensity for blemishes, especially if a good sunscreen is not used.

Still, there are products that use these ingredients in combination. Would that be a problem? According to Thatiana, no. “They are formulated to work together, and the concentrations are adjusted so that they don't cause problems” explains the expert.

"What's not interesting is making product mixtures with these acids that haven't been formulated to work together."



Benzoyl Peroxide + Retinol


When using these ingredients in combination, benzoyl peroxide can negate the effect of Retinol, because it causes the ingredient to oxidize. “If applied together with retinol, which is a vitamin A derivative and acts on the skin, making cell renewal, it increases the chance of peeling and skin sensitization,” explains the dermatologist.



Benzoyl Peroxide + Hydroquinone


Joining hydroquinone with products that contain peroxides can cause negative effects on the skin. This union can result in darkening of the skin in the treated areas, as these ingredients together can cause hypersensitivity, causing erythemia and a slight burning sensation.

However, if this has happened to you, don't worry. Thatiana reveals that this can all be reversed by interrupting the use of these ingredients.



Retinol + Salicylic Acid


These two ingredients have an exfoliating action and, therefore, when used in combination, they can cause irritation and dryness of the skin. According to the dermatologist, when used together they can damage the skin's protective barrier, causing the skin to become dull and dull.



Hydroquinone + Alpha hydroxy acid


At very high concentrations, the use of hydroquinone and high hydroxyoxide can cause skin irritation, redness and peeling. However, used correctly it can be an amazing match!

When asked about the use of these ingredients together, Thatiana reveals that they are both often indicated for lightening blemishes and smoothing the skin.

“Among the benefits of alpha hydroxy acids, glycolic acid is the most famous representative of the AHA group” explains “We can emphasize chemical exfoliation, cell renewal, lightening of blemishes, acne treatment and rejuvenation aid”.



Glycolic Acid + Retinoic Acid


According to the specialist, we should not associate acids such as glycolic and retinoic acid or even Retinol in the skin. This is because, in high concentration, glycolic acid has the function of chemical exfoliation, and retinoic acid, in addition to causing skin renewal, has a greater role in the synthesis of collagen, making the fibers more elastic and giving more firmness and thickness to the skin.

“But not all skin tolerates retinoic acid, especially in the highest concentrations of creams manipulated with a doctor's prescription. It can cause redness, irritation and peeling,” explains Thatiana. "To have a beautiful, lightened and renewed skin usually only one of these 'stars' can be the main actor".

Newsletter

Related Articles

0:00
0:00
Close
UK Heatwave Disrupts Transport, Healthcare and Public Services as Red Weather Alerts Expand Nationwide
Barclays Warns of Growing Cyber Risk Divide Between Large UK Firms and Micro Businesses
European Defence Plans Including Ukraine Integration Prompt UK Strategic Reassessment
UK Equity Markets React as US–Iran Peace Roadmap Eases Oil Price Pressures
United Kingdom Expands Global Clean Energy Partnerships With Brazil, Morocco and Tanzania
Lord David Frost Urges Incoming UK Leadership to Abandon EU Regulatory Reset Strategy
Housing Groups Support Amendment to Strengthen Fire and Gas Safety Access Powers in Social Housing
South London NHS Estates Staff Ballot on Industrial Action Over Pay Structures in Hospital Maintenance Services
United Kingdom Government Invests £60 Million in AI Research Labs at Oxford and University College London
Barclays Cyber Security Report Highlights Rising Threat Exposure Among UK Small Businesses in AI-Driven Attacks
UK Met Office Heatwave Triggers Transport Warnings as Rail Operators Urge Cancellations Amid Infrastructure Strain
South London NHS Estates Workers Ballot for Strike Action Over Pay Disputes Across Major London Hospitals
Barclays Warns of Severe Cyber Security Gap Between Large Corporations and Small Businesses in the United Kingdom
United Kingdom Government Allocates £60 Million for Artificial Intelligence Research Laboratories at Oxford and UCL
National Health Service Approves Teplizumab Treatment to Delay Onset of Type One Diabetes in First European Rollout
Met Office Issues Rare Red Extreme Heat Warning Across London, South East and West Midlands as Transport and Health Systems Face Disruption
Prime Minister Keir Starmer Resigns After Labour Party Revolt Following Economic Stagnation and Local Election Losses
United Kingdom Economy Contracts for Second Consecutive Month as Private Sector Weakens and Job Loss Fears Rise
Taxpayer Support Grows for Higher Digital Levies on Multinational Tech Companies
Bank of England Signals Caution Over Inflation Despite Easing Energy Prices
Lloyds Banking Group Expands Artificial Intelligence Hiring Amid Sector-Wide Automation Shift
Film Producer Corporate Collapse Leaves Creditors Facing Unrecoverable Losses
UK Ten-Year Brexit Anniversary Highlights Ongoing Political and Economic Uncertainty
Nottingham Maternity Scandal Inquiry Reveals Systemic Failings in NHS Care
Met Office Heatwave Prompts Public Health Warnings Across United Kingdom
Concerns Rise Over Fiscal Stability as Political Uncertainty Weighs on UK Borrowing Costs
UK Taxpayers Back Higher Digital Taxes on Global Technology Firms, Survey Shows
Bank of England Holds Interest Rates Steady Amid Persistent Services Inflation
Reform UK and Opposition Leaders Call for General Election Following Starmer’s Departure
Ten Years After Brexit Referendum, UK Faces Ongoing Political Fragmentation and Economic Debate
Nottingham University Hospitals Maternity Inquiry Exposes Severe NHS Failures
Met Office Issues Heat Health Alerts as United Kingdom Faces Record-Breaking Temperatures
Andy Burnham Emerges as Front-Runner for Labour Leadership After Starmer’s Resignation
Keir Starmer Resigns as UK Enters New Phase of Political Leadership Transition
UK Expands Alcohol Ban Enforcement Using Tagging Technology Ahead of World Cup
UK Invests £50 Million in Critical Minerals Supply Chain Security
UK Appoints Special Envoy on Preventing Sexual Violence in Conflict
UK Introduces Fines for Landlords of Unsafe Rental Properties
Reform UK Leads Opinion Polls as Immigration Debate Reshapes UK Politics
Police Investigate Edinburgh Attacks as Potential Hate Crimes
King Charles to Publish Personal Tax and Royal Household Financial Records
Nottingham University Hospitals Maternity Inquiry Report Set for Publication
Heat-Health Alerts Issued Across London and Southern England Amid Rising Temperatures
UK Economy Shows Pressure From Middle East Conflict Despite Modest Growth
Brexit Anniversary Reignites Debate Over UK Economic and Political Direction
UK Parliament Continues Legislative Work Amid Leadership Transition
Financial Markets Hold Steady After UK Leadership Shake-Up
Andy Burnham Enters Labour Leadership Race With Strong Parliamentary Backing
Keir Starmer Resigns as UK Prime Minister After Two Years in Office
Reform UK MP Lee Anderson to Raise Pension Concerns Over British Coal Staff Superannuation Scheme
×