London Daily

Focus on the big picture.
Friday, Jul 17, 2026

A Guide to the Skincare Ingredients You Should Never Mix

A Guide to the Skincare Ingredients You Should Never Mix

We all know oil and water don't mix-but did you know Vitamin C and retinol together are a literal recipe for disaster?

So, you’re finally starting to create a skincare routine-or maybe you’re revamping the one you’ve been following for years. Regardless, when choosing new skincare products, it’s imperative to know which ones will mix and layer well together. Based on your skin type, it might be tricky to figure out which products complement each other the best, and you might go through some trial-and-error. Here, L’OFFICIEL guides you on your new skincare routine with a list of skincare ingredients that you should never mix together.

Alpha Hydroxy Acids + Vitamin C + Retinol


According to the dermatologist, mixing these actives can cause hyper-reactivity of the skin, excessive exfoliation and increased propensity for blemishes, especially if a good sunscreen is not used.

Still, there are products that use these ingredients in combination. Would that be a problem? According to Thatiana, no. “They are formulated to work together, and the concentrations are adjusted so that they don't cause problems” explains the expert.

"What's not interesting is making product mixtures with these acids that haven't been formulated to work together."



Benzoyl Peroxide + Retinol


When using these ingredients in combination, benzoyl peroxide can negate the effect of Retinol, because it causes the ingredient to oxidize. “If applied together with retinol, which is a vitamin A derivative and acts on the skin, making cell renewal, it increases the chance of peeling and skin sensitization,” explains the dermatologist.



Benzoyl Peroxide + Hydroquinone


Joining hydroquinone with products that contain peroxides can cause negative effects on the skin. This union can result in darkening of the skin in the treated areas, as these ingredients together can cause hypersensitivity, causing erythemia and a slight burning sensation.

However, if this has happened to you, don't worry. Thatiana reveals that this can all be reversed by interrupting the use of these ingredients.



Retinol + Salicylic Acid


These two ingredients have an exfoliating action and, therefore, when used in combination, they can cause irritation and dryness of the skin. According to the dermatologist, when used together they can damage the skin's protective barrier, causing the skin to become dull and dull.



Hydroquinone + Alpha hydroxy acid


At very high concentrations, the use of hydroquinone and high hydroxyoxide can cause skin irritation, redness and peeling. However, used correctly it can be an amazing match!

When asked about the use of these ingredients together, Thatiana reveals that they are both often indicated for lightening blemishes and smoothing the skin.

“Among the benefits of alpha hydroxy acids, glycolic acid is the most famous representative of the AHA group” explains “We can emphasize chemical exfoliation, cell renewal, lightening of blemishes, acne treatment and rejuvenation aid”.



Glycolic Acid + Retinoic Acid


According to the specialist, we should not associate acids such as glycolic and retinoic acid or even Retinol in the skin. This is because, in high concentration, glycolic acid has the function of chemical exfoliation, and retinoic acid, in addition to causing skin renewal, has a greater role in the synthesis of collagen, making the fibers more elastic and giving more firmness and thickness to the skin.

“But not all skin tolerates retinoic acid, especially in the highest concentrations of creams manipulated with a doctor's prescription. It can cause redness, irritation and peeling,” explains Thatiana. "To have a beautiful, lightened and renewed skin usually only one of these 'stars' can be the main actor".

Newsletter

Related Articles

0:00
0:00
Close
For 36 Years, He Scammed About 300 Luxury Hotels — Until He Was Caught
Britain Nationalises British Steel to Protect Scunthorpe Production and Strategic Supply
Andy Burnham Takes Labour Leadership and Prepares to Become Britain’s Seventh Prime Minister in a Decade
Tech Companies Want to Move Computing Off Your Screen and Onto Your Body
White House Teleprompter Operator Earned More Than $100,000 From Bets Linked to the President's Speeches
French Prime Minister Survives No-Confidence Vote After Controversial Budget Cuts
European Commission Opens Excessive Deficit Procedure Against France
French Senate Blocks Key Immigration Reform Measures
French Government Pushes EU Action Against Ultra-Fast Fashion Imports
French Parliament Debates Expanded Autonomy Powers for Corsica
France Reopens Autonomy Talks With New Caledonia After Months of Unrest
Bordeaux Wine Producers Seek Three Hundred Million Euro Aid Package After Export Collapse
French Farmers Block Spain Border Crossings Over Imported Food Competition
Cannes Film Festival Bans Fully Artificial Intelligence-Generated Films From Competition
TotalEnergies Shifts More Than Three Billion Euros of Green Investment From Europe to the United States
LVMH Chief Executive Bernard Arnault Presents Succession Plan for Luxury Empire
Kering Reports Fifteen Percent Revenue Drop as Chinese Luxury Demand Weakens
Sanofi Reports Positive Results From Messenger RNA Respiratory Vaccine Trials
France Places Energy Price Caps Under Review to Protect Households Through Winter
EDF Connects Two New Nuclear Reactors to France’s Electricity Grid
Mistral Secures European Commission Contract for Sovereign Artificial Intelligence Models
Renault Opens Next-Generation Electric Battery Plant in Northern France
Air France Signs Two Billion Euro Sustainable Aviation Fuel Deal to Cut Emissions
Marseille Launches Three Billion Euro Port Expansion to Strengthen Mediterranean Trade Role
French-Owned Ubisoft Announces Global Restructuring With Nearly One Thousand Job Cuts
National Railway Operator Suspends Artificial Intelligence Ticket Pricing System After Consumer Backlash
United Kingdom to Ban Sales of High-Caffeine Energy Drinks to Under-Sixteens
Home Office Designates Iranian and Russian Paramilitary Groups as National Security Threats
National Health Service Launches Housing Plan to Retain London Healthcare Workers
British Heatwave Fuels Wildfires and Emergency Evacuations in Scotland
United Kingdom and Estonia Sign Defence Agreement to Strengthen NATO’s Eastern Flank
United Kingdom Cuts Bilateral Aid to African Nations by More Than Eighty Percent
Bank of England Overhauls Banking Rules to Encourage More Lending to Businesses
United Kingdom and India Free Trade Agreement Enters Into Force, Reshaping Bilateral Economic Ties
Andy Burnham Confirmed as New Labour Leader and Prime Minister-Designate
UK Government Faces Pressure Over Extreme Heat Workplace Rules
Lewisham Council Blocks Cooperation With Home Office Immigration Enforcement
UK Parliament Investigates Growing Pressures on Scotch Whisky Industry
Teen Hackers Sentenced Over Thirty-Nine Million Pound Transport for London Cyber Attack
Ministry of Defence Acquires Scottish Fuel Terminal to Strengthen Royal Navy Operations
Bank of England Eases Rules as Economic Growth Remains Weak
Bank of England Governor Warns Andy Burnham on Britain’s Long Economic Stagnation
UK Defence Ministry Buys Scottish Fuel Terminal to Secure Naval Energy Supplies
UK Secures Access to European Defence Contracts Through Ukraine Support Deal
Bank of England Plans Easier Capital Rules to Encourage More Lending
Met Office Says England and Wales Have Already Broken Summer Heat Records
Counter-Terrorism Police Lead Investigation Into Murder of Former Minister Ann Widdecombe
UK Government Nationalises British Steel to Protect Domestic Steel Production
French National Assembly Overrides Senate to Pass Historic Assisted-Dying Legislation
Spanish Prime Minister's Wife Ordered to Stand Trial as Corruption Probes Encircle Governing Party
×