London Daily

Focus on the big picture.
Saturday, Aug 29, 2026

A Guide to the Skincare Ingredients You Should Never Mix

A Guide to the Skincare Ingredients You Should Never Mix

We all know oil and water don't mix-but did you know Vitamin C and retinol together are a literal recipe for disaster?

So, you’re finally starting to create a skincare routine-or maybe you’re revamping the one you’ve been following for years. Regardless, when choosing new skincare products, it’s imperative to know which ones will mix and layer well together. Based on your skin type, it might be tricky to figure out which products complement each other the best, and you might go through some trial-and-error. Here, L’OFFICIEL guides you on your new skincare routine with a list of skincare ingredients that you should never mix together.

Alpha Hydroxy Acids + Vitamin C + Retinol


According to the dermatologist, mixing these actives can cause hyper-reactivity of the skin, excessive exfoliation and increased propensity for blemishes, especially if a good sunscreen is not used.

Still, there are products that use these ingredients in combination. Would that be a problem? According to Thatiana, no. “They are formulated to work together, and the concentrations are adjusted so that they don't cause problems” explains the expert.

"What's not interesting is making product mixtures with these acids that haven't been formulated to work together."



Benzoyl Peroxide + Retinol


When using these ingredients in combination, benzoyl peroxide can negate the effect of Retinol, because it causes the ingredient to oxidize. “If applied together with retinol, which is a vitamin A derivative and acts on the skin, making cell renewal, it increases the chance of peeling and skin sensitization,” explains the dermatologist.



Benzoyl Peroxide + Hydroquinone


Joining hydroquinone with products that contain peroxides can cause negative effects on the skin. This union can result in darkening of the skin in the treated areas, as these ingredients together can cause hypersensitivity, causing erythemia and a slight burning sensation.

However, if this has happened to you, don't worry. Thatiana reveals that this can all be reversed by interrupting the use of these ingredients.



Retinol + Salicylic Acid


These two ingredients have an exfoliating action and, therefore, when used in combination, they can cause irritation and dryness of the skin. According to the dermatologist, when used together they can damage the skin's protective barrier, causing the skin to become dull and dull.



Hydroquinone + Alpha hydroxy acid


At very high concentrations, the use of hydroquinone and high hydroxyoxide can cause skin irritation, redness and peeling. However, used correctly it can be an amazing match!

When asked about the use of these ingredients together, Thatiana reveals that they are both often indicated for lightening blemishes and smoothing the skin.

“Among the benefits of alpha hydroxy acids, glycolic acid is the most famous representative of the AHA group” explains “We can emphasize chemical exfoliation, cell renewal, lightening of blemishes, acne treatment and rejuvenation aid”.



Glycolic Acid + Retinoic Acid


According to the specialist, we should not associate acids such as glycolic and retinoic acid or even Retinol in the skin. This is because, in high concentration, glycolic acid has the function of chemical exfoliation, and retinoic acid, in addition to causing skin renewal, has a greater role in the synthesis of collagen, making the fibers more elastic and giving more firmness and thickness to the skin.

“But not all skin tolerates retinoic acid, especially in the highest concentrations of creams manipulated with a doctor's prescription. It can cause redness, irritation and peeling,” explains Thatiana. "To have a beautiful, lightened and renewed skin usually only one of these 'stars' can be the main actor".

Newsletter

Related Articles

0:00
0:00
Close
UK Hospitality Industry Reports Stronger Summer Trading but Seeks Tax Relief
Reform UK Proposes £30 Tax Credit for Long HMRC Helpline Waits
Labour Debates Caps on Political Donations Ahead of Future Elections
England Accelerates Housing and Planning Reforms Amid Affordability Crisis
NHS Expands Walk-In Community Health Centers to 40 Locations
UK Regulators Expect Meta to Apply Stronger Child Safety Standards Globally
UK Groups Demand Faster Transport Decarbonization After Extreme Summer Weather
UK Launches 10,000 Work Experience Placements as Youth Unemployment Concerns Rise
UK Government Faces Difficult Autumn Budget Choices Over Defense, Spending and Taxes
UK Government Rejects Calls to Slow AI Data Center Expansion
IMF Raises UK Growth Forecast to 1% Despite Global Supply Chain Risks
UK Unsecured Loan Defaults Reach Highest Level Since 2009
UK Energy Price Cap to Rise 4% to Three-Year High of £1,723
More Than 30 Britons Reported Missing After Deadly Nepal-Tibet Floods
Royal Navy Tracks Russian Warships and Sanctioned Vessels in 72-Hour Operation
Police Intensify Investigation Into Organised Crime-Linked Violence in Middlesbrough
UK Small Businesses Face Continued Revenue and Tax Pressures, Federation Says
M&G Real Estate Buys West Sussex Affordable Housing Portfolio for £29 Million
Royal Navy Warship HMS Tamar Visits Cambodia for Regional Security Engagement
UK Government Brings Forward Benefit Payments Ahead of August Bank Holiday
Four Men Plead Guilty to Arson Attack on Jewish Community Ambulances in North London
Ofgem Raises Great Britain’s Household Energy Price Cap by Four Percent From October
UK Government Rejects Green Party Call for Artificial Intelligence Datacentre Moratorium
Millions of UK Benefit Recipients Receive Payments Early Ahead of August Bank Holiday
UK Prime Minister Meets Northern Ireland Leaders in Belfast Over Budget Crisis
Crypto Tax Gains Reach One Point Three Eight Billion Pounds Among UK Investors, HMRC Data Shows
UK Corporate Confidence Rises to Highest Level Since March, Lloyds Survey Shows
Mike Ashley Attacks UK Government Business Rates and Cost-of-Living Policies
Scottish Universities Face Two Hundred Million Pound Annual Funding Gap, Report Warns
Entertainment Figures Urge UK Government to Protect People From AI Voice Cloning
Manchester Airports Group Confirms Customer Data Breached in Cyberattack
Seven Charged Over Vandalism at Donald Trump’s Turnberry Golf Resort in Scotland
Nearly 23,000 UK Households Expected to Move Home on Busiest Day of 2026
UK Benefit Payments to Arrive Early Ahead of August Bank Holiday
Reform UK Pledges to Replace GDPR and Cut Tax Administration Red Tape
Andy Burnham Launches Work Experience Plan for One Million Young People Outside Education or Work
Andy Burnham Faces Labour Backlash After Dropping Support for Political Donations Cap
Andy Burnham Announces UK-Wide Summit With Leaders of Scotland, Wales and Northern Ireland
Met Office Warns of Heavy Rain and Flood Risk Across England and Wales After Summer Heat
Bank of England Warns AI Adoption Could Reduce Demand for Automatable Jobs
UK Confirms National Salmonella Outbreak With More Than 200 Cases
UK Airports Handle Record 81 Million Passengers Despite Middle East Disruption
Ofgem Raises UK Energy Price Cap by Four Percent to £1,723
Cyber Attack Hits Customer Data Systems at Manchester, Stansted and East Midlands Airports
TSA Unveils Major Airport-Security Overhaul as It Drops Gold+ Privatization Plan
CIA Chief Warned Russia Against Attacking NATO in Secret Moscow Mission
Raheem Sterling Charged With Dangerous Driving After Lamborghini Crash
The Secret Dolly Parton Kept Until Her Death: "She Was Much Sicker Than She Let On"
Middlesbrough House Fire Kills Woman and Seven-Year-Old Girl
Prince Harry and Meghan Markle Return to UK Amid Renewed Media Attention
×