London Daily

Focus on the big picture.
Wednesday, Oct 08, 2025

COVID-19: Delaying second dose of Pfizer jab may leave elderly at risk of catching South African variant, study suggests

COVID-19: Delaying second dose of Pfizer jab may leave elderly at risk of catching South African variant, study suggests

Lab tests showed that one dose of the vaccine may not stimulate the immune system to produce enough antibodies to kill the virus.

Delaying the second dose of the Pfizer jab – the current government strategy - may leave some elderly patients at risk of infection by the South African variant, new research suggests.

Lab tests by scientists at Cambridge University showed that one dose of the vaccine may not stimulate the immune system to produce enough antibodies to kill the virus.

Only after a second dose would antibody levels be protective, according to preliminary data in the study, which has not yet been peer-reviewed.

Meanwhile, the South African variant has a mutation called E484K that helps it evade the immune system.

SOUTH AFRICAN VARIANT CASES



Some samples of the Kent variant have now been detected with the same mutation.

The Cambridge researchers tested blood samples from 26 people, 15 of them over 80, who had received one dose of the Pfizer jab against synthetic versions of both variants.

Antibodies in all volunteers were sufficient to kill the Kent variant.

But when the E484K mutation was added 10 times more antibodies were needed to neutralise the virus.

According to researchers, seven people had antibody levels that were insufficient to kill the virus after one dose of the vaccine, all of them over 80.

Only after a second dose, given three weeks later, were their antibody levels boosted to a level that killed the virus.

The study comes on the day Sky News analysis showed the number of deaths in the second wave of COVID-19 infections has now overtaken the number from the first.

Dr Dami Collier, one of the co-investigators, said: "Our data suggest that a significant proportion of people aged over 80 may not have developed protective neutralising antibodies against infection three weeks after their first dose of the vaccine.

"But it's reassuring to see that after two doses, serum from every individual was able to neutralise the virus."

Professor Ravi Gupta, the lead researcher, said: "Our work suggests the vaccine is likely to be less effective when dealing with this (E484K) mutation.

"B1.1.7 [the Kent variant] will continue to acquire mutations seen in the other variants of concern, so we need to plan for the next generation of vaccines to have modifications to account for new variants.

"We also need to scale up vaccines as fast and as broadly as possible to get transmission down globally."

A Department for Health and Social Care (DHSC) spokesperson said the decision to change vaccine dosage intervals (to spread them further apart) had come after a "thorough review of data" which showed the Pfizer/BioNTech vaccine was 89% effective in protection against COVID between 15 to 21 days after the first dose.

A DHSC statement said today's study had "assessed just one aspect of immunity, on a small cohort" and that getting vaccines deployed as quickly as possible to those at risk remained "our number one priority".

It concluded: "The Government is closely following the guidance of the Joint Committee on Vaccination and Immunisation and the UK's four Chief Medical Officers, which recommends we prioritise first doses of vaccine for as many people as possible"

The E484K variant helps the coronavirus evade the immune system and was found in 11 samples of some 200,000 that have been sequenced.

Sky's science correspondent Thomas Moore said the discovery of the E484K mutation was a "worrying development," as it could reduce the effectiveness of COVID vaccines and could also mean those who had been previously infected could be re-infected.

He said the evolution of E484K meant the virus had effectively "developed a superpower" which enabled it to not only infect cells, but also to beat the immune system.

"It changes shape so antibodies don't recognise it in the same way, and the fact that this mutation has been now picked up in some samples of the Kent variant is a twist - a worrying development," said Thomas Moore.

Newsletter

Related Articles

0:00
0:00
Close
France: Less Than a Month After His Appointment, the New French Prime Minister Resigns
Hungarian Prime Minister Viktor Orbán stated that Hungary will not adopt the euro because the European Union is falling apart.
Sarah Mullally Becomes First Woman Appointed Archbishop of Canterbury
Mayor in western Germany in intensive care after stabbing
Australian government pays Deloitte nearly half a million dollars for a report built on fabricated quotes, fake citations, and AI-generated nonsense.
US Prosecutors Gained Legal Approval to Hack Telegram Servers
Macron Faces Intensifying Pressure to Resign or Trigger New Elections Amid France’s Political Turmoil
Standard Chartered Names Roberto Hoornweg as Sole Head of Corporate & Investment Banking
UK Asylum Housing Firm Faces Backlash Over £187 Million Profits and Poor Living Conditions
UK Police Crack Major Gang in Smuggling of up to 40,000 Stolen Phones to China
BYD’s UK Sales Soar Nearly Nine-Fold, Making Britain Its Biggest Market Outside China
Trump Proposes Farm Bailout from Tariff Revenues Amid Backlash from Other Industries
FIFA Accuses Malaysia of Forging Citizenship Documents, Suspends Seven Footballers
Latvia to Bar Tourist and Occasional Buses to Russia and Belarus Until 2026
A Dollar Coin Featuring Trump’s Portrait Expected to Be Issued Next Year
Australia Orders X to Block Murder Videos, Citing Online Safety and Public Exposure
Three Scientists Awarded Nobel Prize in Medicine for Discovery of Immune Self-Tolerance Mechanism
OpenAI and AMD Forge Landmark AI-Chip Alliance with Equity Option
Munich Airport Reopens After Second Drone Shutdown
France Names New Government Amid Political Crisis
Trump Stands Firm in Shutdown Showdown and Declares War on Drug Cartels — Turning Crisis into Opportunity
Surge of U.S. Billionaires Transforms London’s Peninsula Apartments into Ultra-Luxury Stronghold
Pro Europe and Anti-War Babiš Poised to Return to Power After Czech Parliamentary Vote
Jeff Bezos Calls AI Surge a ‘Good’ Bubble, Urges Focus on Lasting Innovation
Japan’s Ruling Party Chooses Sanae Takaichi, Clearing Path to First Female Prime Minister
Sean ‘Diddy’ Combs Sentenced to Fifty Months in Prison Following Prostitution Conviction
Taylor Swift’s ‘Showgirl’ Launch Extends Billion-Dollar Empire
Trump Administration Launches “TrumpRx” Plan to Enable Direct Drug Sales at Deep Discounts
Trump Announces Intention to Impose 100 Percent Tariff on Foreign-Made Films
Altman Says GPT-5 Already Outpaces Him, Warns AI Could Automate 40% of Work
Singapore and Hong Kong Vie to Dominate Asia’s Rising Gold Trade
Trump Organization Teams with Saudi Developer on $1 Billion Trump Plaza in Jeddah
Manhattan Sees Surge in Office-to-Housing Conversions, Highest Since 2008
Switzerland and U.S. Issue Joint Assurance Against Currency Manipulation
Electronic Arts to Be Taken Private in Historic $55 Billion Buyout
Thomas Jacob Sanford Named as Suspect in Deadly Michigan Church Shooting and Arson
Russian Research Vessel 'Yantar' Tracked Mapping Europe’s Subsea Cables, Raising Security Alarms
New York Man Arrested After On-Air Confession to 2017 Parents’ Murders
U.S. Defense Chief Orders Sudden Summit of Hundreds of Generals and Admirals
Global Cruise Industry Posts Dramatic Comeback with 34.6 Million Passengers in 2024
Trump Claims FBI Planted 274 Agents at Capitol Riot, Citing Unverified Reports
India: Internet Suspended in Bareilly Amid Communal Clashes Between Muslims and Hindus
Supreme Court Extends Freeze on Nearly $5 Billion in U.S. Foreign Aid at Trump’s Request
Archaeologists Recover Statues and Temples from 2,000-Year-Old Sunken City off Alexandria
China Deploys 2,000 Workers to Spain to Build Major EV Battery Factory, Raising European Dependence
Speed Takes Over: How Drive-Through Coffee Chains Are Rewriting U.S. Coffee Culture
U.S. Demands Brussels Scrutinize Digital Rules to Prevent Bias Against American Tech
Ringo Starr Champions Enduring Beatles Legacy While Debuting Las Vegas Art Show
Private Equity’s Fundraising Surge Triggers Concern of European Market Shake-Out
Colombian President Petro Vows to Mobilize Volunteers for Gaza and Joins List of Fighters
×