London Daily

Focus on the big picture.
Saturday, Oct 24, 2026

Coronavirus doctor's diary: Don't ask me which vaccine is best, please

Coronavirus doctor's diary: Don't ask me which vaccine is best, please

Dr John Wright of Bradford Royal Infirmary says he's noticed that his medical colleagues show a preference for one vaccine, while members of the public often prefer another. He argues that this isn't a time to be choosy.

The dash for vaccines has thrown up a rather peculiar situation. With so many pharmaceutical companies competing in this greatest of scientific races, we now have a variety of vaccines, and people are starting to ask me, "Do I get a choice?" And "Which vaccine would you recommend?"

The concept of consumer choice when it comes to immunisation, or even medications, is alien. No-one asks about the brand of their annual flu jab, or which company produces the MMR vaccine that will protect their precious children. But the intense global relief that greeted the Pfizer covid vaccine, and then Moderna, AstraZeneca and most recently Novavax and Janssen vaccines (though the last two are still awaiting regulatory approval) has created brand awareness in a population that has had a crash course in epidemiology and infectious diseases.

Elderly people wait for a Covid injection in Milan

My answer is a simple one: we take whatever vaccine we are given and thank the lucky Northern stars that we live in a developed country. The idea of choice seems so wrong, when there is such an acute shortage of vaccines across the world.

In Italy, however, it's reported that police unions are refusing the AstraZeneca vaccine in the belief that the Pfizer and Moderna vaccines are more effective, and some Italian doctors are said to be rejecting it on the grounds that it takes longer to provide immunity. It is still too early to make such claims: as evidence accumulates from the continuation of vaccine trials and real-world evidence we will get a clearer picture.

Comparing vaccines is not as simple as comparing cola drinks or cars. The clinical trials that have reported very early results will continue for their full 12-month duration and the results will become more reliable with time. We have yet to start vaccine trials that can make head-to-head comparisons between different vaccines, so it may be that early results reflect different populations, or dosing regimes.

Side-effects after the vaccines will also vary - some may cause localised problems such as sore arms, others systemic effects such as flu-like symptoms. Again, as vaccine roll-out continues we will get a better picture of these profiles.

Zimbabwe carried out its first Covid vaccinations on Friday, using the Sinopharm vaccine

In my very unscientific straw-polling of preferences I find my medical colleagues have a slight preference for the Pfizer vaccine - they tend to be more comfortable than non-medics with new mRNA technologies and preliminary trial data suggested better clinical effectiveness, which is a key part of all our clinical decision-making.

However when Pfizer's summary trial data was recently released by the US Food and Drug Administration it turned out that over 3,000 suspected but not confirmed cases of Covid were not included in the heavily publicised press releases, so the vaccine may well be less effective than the original 95% claim.

Front-line diary

Prof John Wright, a doctor and epidemiologist, is head of the Bradford Institute for Health Research, and a veteran of cholera, HIV and Ebola epidemics in sub-Saharan Africa. He is writing this diary for BBC News and recording from the hospital wards for BBC Radio.

In my patients and non-medical colleagues there seems to be a greater preference for the AZ vaccine. People are comforted by its made-in-Britain roots, and its more traditional, tried-and-tested viral vector platform, using a harmless virus to deliver the gene for the SARS-CoV-2 spike protein into the patient's body. The Johnson and Johnson vaccine (made by its subsidiary Janssen), takes the same approach.

The Novavax vaccine uses a novel nanoparticle technique - it consists of a laboratory-made SARS-CoV-2 spike protein together with an adjuvant, an agent that signals to the immune system that it must take defensive action. The UK has ordered 60 million doses, so Novavax is likely to be widely used as the roll-out continues.

There is a dismissive scepticism about Russian or Chinese alternatives both among doctors and members of the public, although the effectiveness of the rather scarily named Sputnik V looks pretty good and as yet unpublished results for Sinovac's CoronaVac, which have been circulating in the medical community, also look promising.

Sputnik I was a satellite, Sputnik V is a vaccine

I was due to have my hospital (Pfizer) vaccine just before Christmas, but the SARS-CoV-2 virus nipped in just beforehand and gave me a dose of the real thing. I have held out for a couple of months before re-joining the queue. It is likely that I will maintain a good immune response for the first two or three months, and I feel that while the vaccine is so precious, someone else will benefit more than me, so I would rather give up my dose to those in greater need. However having had possible reinfection already I don't want to push my luck by leaving it too long.

While being choosy about vaccines seems inappropriate to me, the reality is that some older health workers already have a choice and I will soon be in this position myself. My hospital is providing the Pfizer vaccine to all our staff. It will not be so long before my GP offers me the AZ vaccine or possibly the Novavax vaccine that I have been helping to trial, assuming it is licensed by then.

I would of course take any of these vaccines: they have all turned out to work much better than we could have imagined. If I had a choice then it would be an ethical decision. Which vaccine manufacturer reflects the zeitgeist of our collective humanity during the pandemic - the kindness and compassion, the sharing and donating?

I'm impressed by the companies that have offered to make doses available on a not-for-profit basis to low and middle-income countries. Others may have different ways to assess a company's ethics, but this is surely a time when we should encourage the pharmaceutical industry to show us what corporate social responsibility truly means.

Newsletter

Related Articles

0:00
0:00
Close
Tour de France Organizers Confirm Historic Grand Depart Featuring Edinburgh and Yorkshire Stages
National Cyber Security Centre Issues Urgent Alerts Following Global Security Vulnerability in Core Programming Software
Independent Energy Analysts Warn Great Britain Faces Highest Winter Power Tariffs in Europe
Major British Defense Contractors Commit to Delivering Forty Thousand New Apprenticeships and Training Placements
New Bradford Railway Station Infrastructure Project Approved to Transform Regional Transit Connectivity Across Northern England
Welsh Infrastructure Stakeholders Press Government for Accelerated Local Sourcing in Military and Uniform Manufacturing
Scottish Council Governance Crisis Triggers High-Court Legal Challenge Over Leadership Ouster Bid
High Street Bakery Chain Greggs Announces Major Factory Closures and Seven Hundred Job Cuts
Automotive Manufacturer Jaguar Land Rover Advances Advanced Defense Technology Partnership with European Allies
Treasury and Bank of England Officials Signal Persistent Concern Over Inflation-Driven Interest Rate Path
International Monetary Fund Upgrades United Kingdom Growth Forecast While Issuing Inflation Warnings
National Health Service Leaders Warn of Severe Capacity Pressures as Early Winter Respiratory Infections Surge
Government Issues Emergency Resilience Guidance Advising All British Citizens to Stockpile Essential Supplies
United Kingdom Private Sector Growth Beats Expectations in October Driven by Resilient Services and Manufacturing
Barclays to Cut Five Thousand Jobs in Major Artificial Intelligence Adoption and Cost-Cutting Overhaul
Piper Tomahawk Aircraft Crash Near Drymen in Stirling Claims Two Lives as Investigators Deploy
North Sea Transition Authority Approves Jackdaw Gas Field Production After Ministerial Authorization
Government Injects One Hundred and Forty Million Pounds to Expand Urgent Care Ahead of Winter Crisis
Department of Health Warns Further Pay Rises Will Derail National Health Service Waiting List Targets
Major Environmental Emergency Declared in South Wales Following Aerospace Kerosene Spill
Tank Barrel Production Returns to Britain as Defence Contractors Accelerate Domestic Rearmament
Government Approves Controversial Jackdaw Gasfield Development in the North Sea
National Health Service Maternity Safety Review Condemned Over Flawed Artificial Intelligence Integration
Dozens of United Kingdom Government Services Taken Offline Amid Critical Software Vulnerability
Barclays Announces Five Thousand Job Cuts Citing Artificial Intelligence Productivity Gains
Treasury Relaxes Post-Financial Crisis Accountability Rules for City of London Executives
United Kingdom Government Issues Unprecedented Guidance Urging Citizens to Stockpile Essential Supplies
United Kingdom Consumer Inflation Accelerates to Eleven-Month High Driven by Transport Costs
United Kingdom Public Sector Net Debt Breaches Three Trillion Pounds Ahead of Autumn Budget
Department for Science, Innovation and Technology Commits Fifty Million Pounds to Establish Regional Artificial Intelligence Innovation Clusters
Ofgem Directs Major Energy Suppliers to Expand Vulnerable Household Support Funds Ahead of Winter Heating Season
Home Office and National Police Chiefs Council Unveil New Intelligence-Led Strategy to Tackle Organised Immigration Crime Networks
First Minister John Swinney Secures Scottish Parliament Approval for Comprehensive Climate and Green Energy Infrastructure Strategy
National Health Service England and Trades Union Congress Finalize Agreement on Emergency Winter Staffing and Pay Frameworks
HM Treasury and Department for Business and Trade Announce Multi-Billion-Pound Sovereign Investment Pact to Spur Regional Advanced Manufacturing
Bank of England Governor Andrew Bailey Signals Potential for Faster Interest Rate Cuts as Domestic Inflation Pressures Ease Below Forecasts
Parliamentary Inquiry Highlights Urgent Need to Address Housing Shortage as Scottish Completions Hit Eleven-Year Low
United Kingdom and Singapore Sign Comprehensive Financial Agreement to Deepen Digital and Sustainable Market Ties
Greggs Announces Plan to Close Four Manufacturing Facilities and Cut Seven Hundred and Forty Jobs
International Monetary Fund Raises United Kingdom Economic Growth Forecast While Warning of Inflationary Pressures
Energy Security and Net Zero Committee Urges Government to Shift Policy Costs Onto Gas to Lower Household Bills
Housebuilding Across Scotland Plummets to Eleven-Year Low Despite Government Pledges to Tackle National Housing Emergency
Greggs Announces Factory Closures Across Northern England and Scotland Affecting Seven Hundred Forty Jobs
United Kingdom and Singapore Conclude Eleventh Financial Dialogue in Singapore to Deepen Cooperation on Digital Finance and Capital Markets
Energy Security and Net Zero Committee Urges Government to Shift Policy Costs to Gas Bills and Tap Windfall Profits to Lower Consumer Prices
British Broadcasting Corporation Announces Major Cost-Cutting Overhaul to Close Linear Broadcast Services for Television Channels BBC Three and BBC Scotland Alongside Digital Radio Station BBC Radio Four Extra
London Capital Markets Face Renewed Scrutiny After High-Profile Offerings Underperform Post-Listing
Green Party Wins Historic First Westminster Parliamentary By-Election in Gorton and Denton
Environment Secretary Emma Reynolds Unveils Sweeping Regulatory Overhaul for English Water Industry
United Kingdom Health Security Agency Confirms Thirty-Four Cases in Kent Meningitis Outbreak
×