London Daily

Focus on the big picture.
Thursday, Sep 17, 2026

Coronavirus doctor's diary: Don't ask me which vaccine is best, please

Coronavirus doctor's diary: Don't ask me which vaccine is best, please

Dr John Wright of Bradford Royal Infirmary says he's noticed that his medical colleagues show a preference for one vaccine, while members of the public often prefer another. He argues that this isn't a time to be choosy.

The dash for vaccines has thrown up a rather peculiar situation. With so many pharmaceutical companies competing in this greatest of scientific races, we now have a variety of vaccines, and people are starting to ask me, "Do I get a choice?" And "Which vaccine would you recommend?"

The concept of consumer choice when it comes to immunisation, or even medications, is alien. No-one asks about the brand of their annual flu jab, or which company produces the MMR vaccine that will protect their precious children. But the intense global relief that greeted the Pfizer covid vaccine, and then Moderna, AstraZeneca and most recently Novavax and Janssen vaccines (though the last two are still awaiting regulatory approval) has created brand awareness in a population that has had a crash course in epidemiology and infectious diseases.

Elderly people wait for a Covid injection in Milan

My answer is a simple one: we take whatever vaccine we are given and thank the lucky Northern stars that we live in a developed country. The idea of choice seems so wrong, when there is such an acute shortage of vaccines across the world.

In Italy, however, it's reported that police unions are refusing the AstraZeneca vaccine in the belief that the Pfizer and Moderna vaccines are more effective, and some Italian doctors are said to be rejecting it on the grounds that it takes longer to provide immunity. It is still too early to make such claims: as evidence accumulates from the continuation of vaccine trials and real-world evidence we will get a clearer picture.

Comparing vaccines is not as simple as comparing cola drinks or cars. The clinical trials that have reported very early results will continue for their full 12-month duration and the results will become more reliable with time. We have yet to start vaccine trials that can make head-to-head comparisons between different vaccines, so it may be that early results reflect different populations, or dosing regimes.

Side-effects after the vaccines will also vary - some may cause localised problems such as sore arms, others systemic effects such as flu-like symptoms. Again, as vaccine roll-out continues we will get a better picture of these profiles.

Zimbabwe carried out its first Covid vaccinations on Friday, using the Sinopharm vaccine

In my very unscientific straw-polling of preferences I find my medical colleagues have a slight preference for the Pfizer vaccine - they tend to be more comfortable than non-medics with new mRNA technologies and preliminary trial data suggested better clinical effectiveness, which is a key part of all our clinical decision-making.

However when Pfizer's summary trial data was recently released by the US Food and Drug Administration it turned out that over 3,000 suspected but not confirmed cases of Covid were not included in the heavily publicised press releases, so the vaccine may well be less effective than the original 95% claim.

Front-line diary

Prof John Wright, a doctor and epidemiologist, is head of the Bradford Institute for Health Research, and a veteran of cholera, HIV and Ebola epidemics in sub-Saharan Africa. He is writing this diary for BBC News and recording from the hospital wards for BBC Radio.

In my patients and non-medical colleagues there seems to be a greater preference for the AZ vaccine. People are comforted by its made-in-Britain roots, and its more traditional, tried-and-tested viral vector platform, using a harmless virus to deliver the gene for the SARS-CoV-2 spike protein into the patient's body. The Johnson and Johnson vaccine (made by its subsidiary Janssen), takes the same approach.

The Novavax vaccine uses a novel nanoparticle technique - it consists of a laboratory-made SARS-CoV-2 spike protein together with an adjuvant, an agent that signals to the immune system that it must take defensive action. The UK has ordered 60 million doses, so Novavax is likely to be widely used as the roll-out continues.

There is a dismissive scepticism about Russian or Chinese alternatives both among doctors and members of the public, although the effectiveness of the rather scarily named Sputnik V looks pretty good and as yet unpublished results for Sinovac's CoronaVac, which have been circulating in the medical community, also look promising.

Sputnik I was a satellite, Sputnik V is a vaccine

I was due to have my hospital (Pfizer) vaccine just before Christmas, but the SARS-CoV-2 virus nipped in just beforehand and gave me a dose of the real thing. I have held out for a couple of months before re-joining the queue. It is likely that I will maintain a good immune response for the first two or three months, and I feel that while the vaccine is so precious, someone else will benefit more than me, so I would rather give up my dose to those in greater need. However having had possible reinfection already I don't want to push my luck by leaving it too long.

While being choosy about vaccines seems inappropriate to me, the reality is that some older health workers already have a choice and I will soon be in this position myself. My hospital is providing the Pfizer vaccine to all our staff. It will not be so long before my GP offers me the AZ vaccine or possibly the Novavax vaccine that I have been helping to trial, assuming it is licensed by then.

I would of course take any of these vaccines: they have all turned out to work much better than we could have imagined. If I had a choice then it would be an ethical decision. Which vaccine manufacturer reflects the zeitgeist of our collective humanity during the pandemic - the kindness and compassion, the sharing and donating?

I'm impressed by the companies that have offered to make doses available on a not-for-profit basis to low and middle-income countries. Others may have different ways to assess a company's ethics, but this is surely a time when we should encourage the pharmaceutical industry to show us what corporate social responsibility truly means.

Newsletter

Related Articles

0:00
0:00
Close
Asthma Charity Warns of Major Gaps in Childhood Diagnostic Testing Across England
TUC Chief Paul Nowak Appointed to Bank of England Court
Bristol Opens £35 Million Deep-Tech Innovation Hub at Temple Quarter
Oxfordshire Village Votes Symbolically to Leave UK Over Asylum Housing Plan
Andy Burnham Deepens UK Defense and AI Cooperation With NATO and Canada
UK Government Announces Neonatal Safety Reforms After Thirlwall Inquiry
Bank of England Weighs Rate Decision as UK Inflation Rises to 3.1%
UK Health Unions Warn of Staffing Pressures as Public and Private Pay Growth Diverges
Rockstar Games Faces Tribunal Claims From 23 Former Grand Theft Auto VI Developers
UK Treasury Faces Tighter Budget Constraints as Borrowing Costs and Pension Spending Rise
Prime Minister Andy Burnham Sets Out Ten-Year Plan for Greater Public Oversight of Utilities
UK Economy Grows 0.4% in July as Services and Technology Activity Strengthen
Scotland, Wales and Northern Ireland Leaders Coordinate Push for UK Constitutional Change
Police Tighten Public-Order Measures After Anti-Immigration Protests in Dover and Portsmouth
UK Ministers Pressed for Answers After US Diplomat Accused of Child Abuse Images Leaves Britain
Jaguar Land Rover Pursues NATO Defense Contracts for Defender Vehicles
British Service Member Dies in Road Accident While Deployed in Ukraine
George Osborne Calls for Britain to Rejoin EU Customs Union
Anthropic Chief Dario Amodei Urges Faster UK Action on Advanced AI Risks
UK State Pension Set for 3.9% Rise Under Triple Lock
UK Labour Market Cools as Payrolled Employment Continues to Decline
Reform UK’s £72 Million in Donations Faces Scrutiny Under Proposed Retrospective Funding Rules
UK Doctors Warn Expanded Pharmacy First Scheme Could Put Patients at Risk
British Airlines Cut Short-Haul Capacity as Jet Fuel Costs Rise
UK News Publishers Forecast 40% Search Traffic Drop as AI Overviews Expand
Axel Springer Wins Approval for £575 Million Daily Telegraph Acquisition
London Mayor Sadiq Khan Opposes Heathrow Third Runway Over Climate Targets
Scotland, Wales and Northern Ireland Leaders Hold Summit Seeking Greater Autonomy
UK Energy Price Cap Set to Rise to £1,723 in October
UK Treasury Warns Middle East Conflict Is Threatening Economic Growth
Labour Moves to Retrospectively Cap Overseas Political Donations After Reform UK Funding Surge
HMRC Warns Nearly Seven Million Adults Are Unclear About State Pension Entitlements
UK Parliament Passes Sovereign Grant Reform Before Conference Recess
British Rail Passengers Gain Automatic Right to Switch Operators During Disruptions
Burnham Hosts Downing Street Business Summit as UK Fiscal Pressure Builds
Labour Government Moves to Challenge £72 Million in Reform UK Crypto Donations
UK Advertising Industry Warns Wider Junk Food Rules Could Put £1 Billion in Media Spending at Risk
Cornwall Opens Devolution Talks With UK Government Over Transport and Local Services
UK Parliament Considers Sovereign Grant Reform Setting Royal Funding at £99.9 Million
Trades Union Congress Calls for Income-Based Energy Tariff Funded by Higher Bank Levy
UK Prime Minister Rejects Second Scottish Independence Referendum
House of Lords Begins Scrutiny of Bill to Lower UK Voting Age to 16
Anthropic Says Claude Was Exploited in Weapons-Related and State-Linked Cyber Activity
Institute of Directors Urges UK Government to Avoid Business Tax Increases in Autumn Budget
Rising Gilt Yields Cut UK Fiscal Headroom to About £13 Billion Ahead of Budget
UK Economy Grows 0.4% in July as Services and Technology Activity Strengthen
UK Government Promises Clearer Student Loan Guidance After Repayment Backlash
Charities Warn Unpaid Carers May Die Before Receiving Government Compensation
Dover Unrest Prompts Review of UK Counter-Extremism Strategy
Celtic Summit Leaders Reassert Right to Pursue Independence From UK
×