London Daily

Focus on the big picture.
Monday, Dec 04, 2023

The Biden administration is gambling that a little-studied vaccine can stop monkeypox

The Biden administration is gambling that a little-studied vaccine can stop monkeypox

To prevent the disease from becoming endemic, the U.S. needs a vaccine that stops transmission, but no one knows if Jynneos does that.

Since monkeypox began its unprecedented spread through the nation in May, more than 352,600 people in the U.S. have placed their trust in a vaccine that has never undergone trials to evaluate how well it fights the virus in humans.

The vaccine was designed to prevent smallpox, a related virus, and studies conducted by its Danish manufacturer have shown it works against monkeypox too, in animals.

Much less is known about how it works in people. But the Biden administration is gambling not only that it will work, but also that it can stop another debilitating, communicable disease from becoming endemic in the U.S., as it has been for decades in parts of Africa. The risks of the strategy are real: If the vaccine comes up short, Americans will have another disease to live with, and health officials will almost certainly further damage confidence in public health.



Many scientists support the effort, saying the benefit of getting vaccinated outweighs the risk. And as the vaccination campaign has gained steam this summer, the number of new cases appears to be slowing. But the long list of unknowns is daunting. “We don’t know exactly how effective this vaccine is in the real world,” said Abraar Karan, an infectious disease doctor at Stanford University. “How well does it work? What does it do? What doesn’t it do? How well does it stop viral shedding versus severe disease versus risk of getting infected at all?”

A clear picture of how well the vaccine, Jynneos, will protect Americans against the disease, which can cause flulike symptoms, a painful rash and scarring, does not exist. Already, more than 19,400 Americans have caught it. The World Health Organization has warned against relying on the vaccine alone, citing scattered “breakthrough” infections in vaccinated people in Europe. And a new study in the Netherlands, which has not been peer reviewed, suggested that the vaccine produces relatively low levels of antibodies.

“The Jynneos vaccine was approved by the FDA with very, very little data compared to other vaccines and absolutely no clinical efficacy data,” said William Moss, executive director of the International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health. “This is a very unusual circumstance.”
In a Sept. 1 report, the Centers for Disease Control & Prevention noted there is significant uncertainty over

the long-term trajectory of the U.S. outbreak due to several unknown factors, including the vaccine’s ability to prevent infection, “versus minimizing severe disease.” The report noted that “low-level transmission could continue indefinitely.” On Friday, the White House said it was asking Congress for $3.9 billion in emergency funding to help contain the outbreak, part of which would go toward studying vaccine effectiveness.

Bavarian Nordic, the Danish manufacturer, ran clinical trials that showed Jynneos was safe and produced the same immune response as an older smallpox shot in humans. But evaluating a vaccine’s immune response isn’t the same as studying its real-world efficacy. For monkeypox, the only efficacy studies the firm conducted were in macaques. The results were enough for the FDA, which greenlit Jynneos for both smallpox and monkeypox in 2019.

It’s one of two vaccines in the Strategic National Stockpile that can be used against monkeypox; the other, ACAM2000, is the older smallpox vaccine and can have dangerous side effects, including inflammation of the heart. It is not recommended for people who are immunocompromised.

Data from Africa suggests smallpox vaccines are 85 percent effective in preventing monkeypox, according to the CDC.

But the strain now spreading in the U.S. is different from the one that’s prevalent in Africa. It’s causing different symptoms and transmitting mainly through close, intimate contact, primarily among men who have sex with men.

“Do we think that this vaccine is safe? Yes. Do we think that this vaccine will provide some protection, in particular against severe disease and death? Absolutely,” said Anne Rimoin, a professor of epidemiology at UCLA. “Is it going to provide protection against infection and transmission? That we don’t know.”

Given the options — ACAM2000, Jynneos, or waiting for better data while the outbreak spreads unchecked — public health officials had no real choice, said William Schaffner, medical director at the National Foundation for Infectious Diseases.

“The equation solves unequivocally in favor of Jynneos,” Schaffner said. “That’s clearly better than doing nothing, and, in my mind, doubly clearly better than using ACAM2000.”

The U.S. government has so far shipped more than 770,000 Jynneos vials to 50 states and U.S. territories. After shortfalls in supply, the FDA authorized its use in partial doses based on a small 2015 study, adding yet another layer of uncertainty to the rollout now that people are receiving less vaccine.

The National Institutes of Health and the CDC are now setting up studies to learn more about how Jynneos works in people. Rimoin is also working with colleagues in Los Angeles to jump-start vaccine effectiveness studies, in addition to working in the Democratic Republic of Congo to improve monkeypox surveillance and outbreak investigation in the region.

There won’t be any immediate answers. “Initial estimates of vaccine effectiveness will take some time,” a CDC spokesperson told POLITICO.


A ‘neglected’ disease


Frustrated scientists have long warned of a global monkeypox outbreak. After smallpox was eradicated in 1980, routine vaccination against the virus ended.

Monkeypox was known then to be crossing from animals to humans in parts of Central and West Africa, and scientists worried that as herd immunity for smallpox dwindled, monkeypox could take its place.

Despite that threat — and a steady increase in monkeypox outbreaks in the intervening decades in Africa, including evidence of human-to-human spread in a large 2017 outbreak in Nigeria — research on the disease has been woefully insufficient, scientists say.

“We’ve neglected this disease in Africa for many, many years,” said David Heymann, a professor of infectious disease epidemiology at the London School of Hygiene and Tropical Medicine during a recent briefing by the American Public Health Association and the National Academy of Medicine. Decades after it was first asked, he noted, the question remains: “Will human monkeypox replace smallpox? ... We still don’t know.”

Jynneos’ origins date to Dryvax, one of the first generation vaccines used in the global smallpox eradication effort whose unique method of administration left a small, round scar on arms across the world in the 20th century.

Dryvax, which also provided protection against monkeypox, stopped being manufactured after smallpox was eradicated. After the attacks of Sept. 11, 2001 — amid fears that terrorists or a hostile foreign government could weaponize smallpox — the U.S. poured money into coming up with a new vaccine.

The first offering was ACAM2000. Cambridge, Mass.-based Acambis, which Sanofi has since purchased, derived it from Dryvax. It won FDA approval in 2007, establishing its efficacy not through clinical trials but by producing an equivalent “take rate,” a red sore spot at the site of the vaccination, as Dryvax.

Later, Bavarian Nordic developed Jynneos as a safer option. Determining its efficacy for smallpox was based on the amount of antibodies it produced, compared to ACAM2000, and it was also tested against monkeypox in animals.

The approach was unusual, in some experts’ opinion, but there was a good reason for it. “We could not do the standard clinical trials to assess the efficacy of these vaccines against smallpox because there was no smallpox transmission,” said Moss of Johns Hopkins. “Even monkeypox outbreaks were not large enough to do clinical efficacy trials.”

And smallpox, a deadly scourge for much of human history, was the focus. Monkeypox is far less deadly, and the strain that is circulating in the U.S. now is less dangerous than another strain that is also endemic in parts of Africa. Only one U.S. patient, who suffered from serious underlying conditions, has died with the disease during the current outbreak.

When it first sought FDA approval for Jynneos in the U.S., Bavarian Nordic did not even ask about monkeypox. The FDA requested that it add monkeypox to its application, Paul Chaplin, Bavarian Nordic’s CEO told POLITICO.

In the FDA’s approval paperwork, the agency noted that after Bavarian Nordic’s initial application, “inquiries were received from external stakeholders in the US government asking whether the available data for [Jynneos] would support an indication for prevention of monkeypox to make available an effective countermeasure for this disease.”

The FDA did not respond to requests for information about the change. But given a small 2003 outbreak of monkeypox in the U.S., and the 2017 outbreak in Nigeria that epidemiologists believe is linked to the current outbreak, somebody appeared to be concerned.

Last year, Rimoin received funding from the U.S. military’s Defense Threat Reduction Agency to work with countries in Central Africa where monkeypox is endemic to improve surveillance of the disease, how outbreaks are investigated, and create a training hub. The project, called the Monkeypox Threat Reduction Network, has enough funding “to get things off the ground,” she said, but it’s not enough to do this work across the region.

Since the global outbreak, she said there’s been more interest in the project, but the U.S. government has not stepped up with new funding. It’s part of a broader lack of investment that has left the Biden administration struggling to keep up with yet another unpredictable public health emergency, she said.

“We haven’t been willing to invest in the infrastructure. We want to have an excellent system, with excellent surveillance and case detection and rapid deployment of vaccines and rapid development of diagnostics to be able to answer the questions that are currently salient to the population right now,” she said. “That is where we always get ourselves into trouble.”


‘Outstanding questions’


During the recent American Public Health Association briefing, Boghuma Kabisen Titanji, an assistant professor of infectious diseases at Emory University, shared a slide posing a series of “outstanding questions” about the two available monkeypox vaccines.

“How effective are these vaccines against monkeypox? How durable is the immunity they confer? Will boosters be needed? If yes, how soon?”

Her list went on.

A full picture of how Jynneos works will need to include an evaluation of the strategy the administration has adopted to stretch the nation’s limited vaccine supply, reducing the size of doses and administering them between skin layers rather than below.

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is in the process of setting up clinical trials to study what level of antibodies the vaccine — administered both in full and partial doses — generates in the population, in the event the virus spreads widely.

But while those studies will eventually show what level of antibodies the vaccine produces, they won’t answer other critical questions, such as how those antibodies impact the severity of the disease, or how long vaccine protection lasts.

“There hasn’t been enough disease to know at what point you are at risk again,” said John Beigel, associate director for clinical research in NIAID’s division of microbiology and infectious diseases, who is designing the clinical trials. “We don’t know the duration of protection.”

There are also efforts underway to understand why some people are developing breakthrough infections, Beigel said, adding that “we’re nowhere close to knowing the answer.”

Chaplin, Bavarian Nordic’s CEO, said the company was “in discussions” with the U.S. and European governments about supporting effectiveness studies.

The CDC spokesperson, who was granted anonymity to discuss plans that aren’t yet finalized, said the agency is developing a “portfolio of vaccine effectiveness projects” that will gather this kind of data from “various locales, populations, and timepoints.” Some related work has begun, including an investigation in Washington, D.C., to evaluate infections among persons seeking vaccination.

The agency has also urged men who have sex with men to limit their intimate contact to reduce the chance of infection.

There are early signs the government’s strategy is working. New U.S. cases appear to be growing more slowly than earlier in the summer. But it’s not yet known whether that’s because the vaccine is doing what administration officials hope it will, or because the communities impacted by the virus have changed their behavior, or both.

Scientists caution that behavioral change, while critical in controlling the current outbreak and preventing disease, isn’t a long-term solution in places where the virus has a foothold. It appears to be spreading mainly through sexual contact, but not always.

“This is a really important time to be collecting data on the safety and effectiveness of this vaccine,” said Moss. “This needs to be done. This is the time to do it.”

To avoid the loss of faith that has accompanied the Covid-19 vaccination campaign, the government needs to publicize what information it has — and what it doesn’t — so people know how much they can rely on the vaccine, and feel public health officials are being open with them, experts said.

“The government or the medical community or somebody has to lay out what we know, and what we don’t know,” said Bruce Gellin, chief of global public health strategy at the Rockefeller Foundation. “And then if we learn something that’s different than what we expect, we’ll tell you about it. It’s all about the transparency.”

Comments

Oh ya 1 year ago
They only tested the new Chinese shot on 8 mice and the FDA approved it last week so why worry about this one. Throw it out and the sheeple will run to get it. It can be part of the world wide IQ test that billions failed

Newsletter

Related Articles

London Daily
Close
0:00
0:00
Ant and Dec, our favorite jungle jesters, have thrown a curveball. They're suggesting a 'politician-free' season of 'I'm A Celebrity. Get Me Out Of Here!'
You Are So Beautiful
Trump’s lawyers say he did not take an oath ‘to support the Constitution’
Postmodern Jukebox European Tour Version
Henry Kissinger, the influential American diplomat, Nobel Peace Prize laureate, and former Secretary of State, passed away at 100 at his Connecticut home.
An old French tune (by Georges Brassens) Pomplamoose ft. John Schroeder
Thai Deputy Prime Minister and Foreign Minister Dr. Parnpreeb Commends ICRC's Role in Hostage Release
Sattahip Motor Show 20
Sam Bankman-Fried, founder of the crypto exchange FTX who was convicted of fraud earlier this month, is adjusting to his new life in the detention center where he awaits sentencing.
SONATE AU CLAIR DE LUNE - Moonlight sonata
Sam Bankman-Fried, founder of the crypto exchange FTX who was convicted of fraud earlier this month, is adjusting to his new life in the detention center where he awaits sentencing.
A kiss to build a dream on
The political network founded by the billionaire industrialist brothers Charles and David Koch has endorsed Nikki Haley in the Republican presidential nominating contest
Wonderful Tonight - Eric Clapton (Boyce Avenue acoustic cover)
Charlie Munger, Warren Buffett's longtime investing partner, dies at 99
Mean Blues
Robert De Niro told an awards ceremony a speech he was reading had been edited without his knowledge, removing critical comments about Donald Trump
La Chansonnette
Standard Chartered is in the early stages of a search for its next chair as the bank prepares for the departure of Jose Vinals, who’s entering his eighth year in the role
Pattaya Addicts
Eurostar to Suspend Amsterdam to London Service for 6 Months
Franz Liszt - Liebestraum - Love Dream
California is not considered a racist place. Or so it seems.
Dream a little dream of me
Sam Altman's return to OpenAI marks a significant turn of events for Microsoft and its relationship with the AI giant.
Unchained Melody sung like you've NEVER heard!
Radical immigrants set on fire police cars and loot shops in Dublin.
Dave Brubeck - Take Five
The BBC Caught Again with Questionable Journalistic Standards, as Ugly Facts Undermine Its Attractive Yet Flawed Arguments
Édith Piaf - Non, Je Ne Regrette Rien (Sofie)
This video reveals that Target's Black Friday promotions are entirely fake, with no actual discounts. The prices before and after are identical!
Rondo Alla Turca
Israel's Spokesperson Mark Regev's Response to Comparisons Between Palestinian Teenage Terrorists and Young Innocent Victims of Hamas Captivity
Kiss of fire
Here is a video showing the moment of the release of the captives by the terrorist organization Hamas and their transfer to the Red Cross on their way back to the State of Israel.
Tom Jones - I´ll Never Fall In Love Again 1967, 1989, 2001
Here is a video showing the moment of the release of the captives by the terrorist organization Hamas and their transfer to the Red Cross on their way back to the State of Israel.
Israel Cachao López - Guajira Clásica
Bill Gates Envisions a Possible 3-Day Work Week with AI
Edward Maya - Stereo Love (feat. Vika Jigulina) (Extended Mix)
Viktor Orban's Provocative Assertions and Their Significance in Europe
Strauss - Radetzky March - Karajan
Orban's Blunt Challenge to Brussels: Embracing National Sovereignty in Migration Policy
La vie en rose
OpenAI Staff Rebellion: 500 Employees Demand Board Resignation in Dramatic Standoff
The Temptations - My Girl (Smokey Robinson Tribute) 2006 Kennedy Cent
OpenAI Staff Rebellion: 500 Employees Demand Board Resignation in Dramatic Standoff
Orlando Cachaito Lopez Redencion
Over 200 Convicted in Italy's 'Ndrangheta Mafia Trial
Edith Piaf - NON, JE NE REGRETTE RIEN
In a scandalous revelation at the COVID-19 inquiry, UK Prime Minister Rishi Sunak is under fire for an alleged remark that suggests a chilling indifference to human life during the pandemic
RADETZKY MARCH-2008-Wien, New Year Concert
Abu Dhabi-Backed Fund Poised to Assume Control of UK's Telegraph Media Group
Only you (And you alone)
Sam Altman and Greg Brockman Join Microsoft Amidst OpenAI Developments
Strangers In The Night
Reporters Without Borders Unveils News Platform to Counter Russian Propaganda
Charles Aznavour - La Boheme
Singer Shakira will pay a fine of eight million euros after being accused of evading taxes worth 14.5 million euros during the years 2012-2014.
Summer time
Hungary's Orbán Asserts Ukraine Is Far from EU Membership
Sting and Stevie Wonder - Fragile (from Sting's 60th birthday concert)
Racial Bias in AI Leads to Wrongful Arrest Due to False Recognition
Aux Champs Elysees
Orban Stresses Hungary's Need to Reform the EU Rather Than Exiting It
Stand By Me - Ben E. King (Boyce Avenue acoustic cover)
Biden Advocates for Palestinian Authority to Govern Gaza and West Bank
La Mer (Beyond the Sea) – Avalon Jazz Band
Brigitte Macron Opens Up About Her Marriage to Younger President Emmanuel Macron
She
Apple and Disney Halt Ads on X Following Elon Musk's Antisemitic Post, US Reacts
Nathalie Song by Enzo Petrachi Stjepan Hauser Cello
Finland Shuts Four Crossing Points on Russia Border
Shape of My Heart - Sting (Boyce Avenue acoustic cover)
Viktor Orbán Welcomes Cameron's Political Return
Radiohead - Creep
The UK’s Supreme Court, in a move that surprised no one who respects international law and human rights, has just delivered a landmark ruling against Prime Minister Rishi Sunak’s immigration strategy.
Quizás,Quizás,Quizás - Andrea Bocelli - Jennifer Lopez
YouTube has introduced an AI feature named Dream Track that can mimic the voices of celebrities such as Demi Lovato and John Legend, enabling users to compose brief songs by specifying lyrics and mood
Perhaps, Perhaps, Perhaps - Multi-Couples
Viktor Orbán Welcomes Cameron's Political Return
Pentatonix Havana
The UK’s Supreme Court, in a move that surprised no one who respects international law and human rights, has just delivered a landmark ruling against Prime Minister Rishi Sunak’s immigration strategy.
Paula Cole - Autumn Leaves
AWS, Google, and Microsoft to Invest $8.5 Billion in Thailand
Oscar Benton Bensonhurst Blues
Top German journalist received €600,000 from Putin ally, leak reveals
OH NANANA vs ABUSADAMENTE
A Dramatic Video from Gaza, Provided by IDF Spokesperson Daniel Hagari, Offers Undeniable Evidence of Hamas Establishing Terror Operation Bases Near Schools, Above Hospitals, and Inside Civilian Areas.
Nina Simone - ”I Put A Spell On You”. Vezi aici cum cântă Jeremy Ragsd
FBI Agents Confiscate Electronic Devices of New York Mayor
NIGHTWISH - The Phantom Of The Opera
Moody's Downgrades U.S. Credit Outlook to Negative Amid Fiscal Concerns
Motorshow 2016 Tanjay Negros Oriental
Significant security measures set in place by Scotland Yard this Remembrance weekend in London
Monica Bellucci - Ti Amo
Paper straws found to contain long-lasting and potentially toxic chemicals - study
Michael Jackson - Billie Jean Milena The Voice France 2018
FTX's Bankman-Fried headed for jail after judge revokes bail
Michael Buble (Help Me Make It Through The Night) feat Loren Allred
Memories Canon In D - Maroon 5 (Boyce Avenue piano acoustic cover)
Matteo Simoni - Marina
Maroon 5 - One More Night
Maroon 5 - Memories
Mark Knopfler - Brothers In Arms (Berlin 2007 Live)
Mark Knopfler & Emmylou Harris - Romeo And Juliet (Real Live Roadrunni
Marina, Marina - The LUCKY DUCKIES intimist live concert at Guimarães
Major Lazer & DJ Snake – Lean On Mauranne The Voice France 2016
Love Theme from Romeo and Juliet - Joslin - Henri Mancini, Nino Rota
LoLa & Hauser - Love Story
Linkin Park Jay-Z - Numb Encore (Live 8 2005)
Hallelujah Mennel Ibtissem, The Voice France Leonard Cohen
Leonard Cohen - Dance Me to the End of Love
Leonard Cohen & Natasha Rostova - Dance me to the end of love
La casa de papel - Bella Ciao
La Camisa Negra
L'italiano (Toto Cutugno) - The Gypsy Queens
Juanes - La Camisa Negra
Jonathan and Charlotte - Britain's Got Talent 2012 Live Semi Final - U
John Powell - Assassin's Tango
Joe Cocker - You Can Leave Your Hat On (LIVE in Dortmund)
Joe Cocker - Unchain My Heart 2002 Live
Joe Cocker - A Whiter Shade Of Pale
Jay Z & Alicia Keys - Empire State of Mind LIVE
Jason Mraz - Im Yours (live)
Jarrod Radnich - Bohemian Rhapsody - Virtuosic Piano Solo
James Blunt - You're Beautiful
James Blunt - You're Beautiful & Bonfire Heart (Live at The Nobel Peac)
If You Go Away - Helen Merrill & Stan Getz (Tribute to Virna Lisi)
I'LL BE MISSING YOU
I Say a Little Prayer
Hotel California ( Eagles ) 1994 Live
Historia de un amor - Luz Casal. Vezi interpretarea Biancăi Sumanariu
Here Comes The Sun - The Beatles (Boyce Avenue acoustic cover) on Spot
Heart - Stairway to Heaven Led Zeppelin - Kennedy Center Honors
HAVANA by Camila Cabello Zumba Pre Cooldown TML Crew Kramer Pastra
HAUSER and Señorita - I Will Always Love You
HAUSER - Waka Waka
HAUSER - Sway
HAUSER - Lambada
HAUSER - Historia de un Amor
HAUSER - Despacito
Great Pretender
Georgia May Foote & Giovanni Pernice Samba to 'Volare' - Strictly Come
Gary Moore - Still Got The Blues
GIPSY KINGS VOLARE Penelope Cruz
Fugees - Killing Me Softly With His Song
French Latino - Historia de un Amor
For A Few Dollars More The Danish National Symphony Orchestra (Live)
Flashdance • What a Feeling • Irene Cara
Filip Rudan - “Someone You Loved” Audicija 4 The Voice Hrvatska Sez
Eric Clapton - Wonderful Tonight
Enya - Only Time
Enrique Iglesias - Bailando (English Version) ft. Sean Paul
Enrique Iglesias - Bailamos
Elena Yerevan Historia de un amor
Ed Sheeran - Shape of You (Official Music Video)
Ed Sheeran - Perfect Symphony [with Andrea Bocelli]
Ed Sheeran - Perfect (Official Music Video)
Easy On Me - Adele (Boyce Avenue 90’s style piano acoustic cover) on S
ERA - Ameno
ELENA YEREVAN- Cancion Del Mariachi-IN STUDIO-2017 DPR
Dust In The Wind - Kansas (Boyce Avenue acoustic cover)
Don't Let Me Be Misunderstood
Despacito x Shape Of You - Pentatonix
Deep Purple - Child In Time - Live (1970)
David Foster When A Man Loves A WomanIt's A Mans World (SealMichael Bo
Dance me to the end of Love ( Pi-Air Design )
Coolio - Gangsta's Paradise (feat. L.V.) [Official Music Video]
Conquest Of Paradise (Vangelis), played on Böhm Emporio organ
Cielito Lindo
Chico & The Gypsies - Bamboleo
Canción Del Mariachi - Antonio Banderas, Los Lobos • Desperado
Camila Cabello - Havana (Audio) ft. Young Thug
Camila Cabello - Havana ( cover by J.Fla )
California Dreamin' - The Mamas & The Papas José Feliciano (Boyce Ave
Buster Benton - Money Is The Name of The Game
Hallelujah Pentatonix
Bobby McFerrin - Don't Worry Be Happy (Official Music Video)
Bob Dylan - Knockin' On Heaven's Door Emilia The Voice Kids France
Besame Mucho - Cesaria Evora
Ben E. King - Stand by Me Sax Cover Alexandra Ilieva Thomann
Bella Ciao
Bella Ciao - INSTRUMENTAL
Beautiful in White x Canon in D (Piano Cover by Riyandi Kusuma)
Bad Romance - Vintage 1920's Gatsby Style Lady Gaga Cover ft. Ariana Savalas & Sarah Reich(1)
BELLA CIAO 2020 - KARAOKE ITALIANO
BAMBOLEO - Gipsy Kings • Antonio Banderas, Katya Virshilas
BAILANDO (original)
Awesome Ukrainian yodeler - SOFIA SHKIDCHENKO (with English subtitles)
Avicii - The Nights
Atom - The Great Gig in the Sky
Aretha Franklin - (You Make Me Feel Like) A Natural Woman (Official Ly
Antonio Banderas - Cancion del Mariachi (Desperado)
André Rieu - Zorba's Dance (Sirtaki)
André Rieu - Can't Help Falling In Love
André Rieu & Mirusia - Ave Maria
Andrew Reyes Elton John - Don't Let The Sun Go Down The Voice 2020 (
Andreas Kümmert Whiter Shade Of Pale The Voice of Germany 2013 Showd
And I Love You So
All About That Bass - Postmodern Jukebox European Tour Version
Alan Walker - Faded (Piano Cover)
Ain't No Sunshine -- Bill Withers (cover by Canen 12 y.o.)
African music
Adriana Vidović - “Creep” Audicija 4 The Voice Hrvatska Sezona 3
Adriana Vidović - “Believer” Nokaut 3 The Voice Hrvatska Sezona 3
A Fistful of Dollars - The Danish National Symphony Orchestra and Tuva
4 Beautiful Soundtracks Relaxing Piano [10min]
2CELLOS - Whole Lotta Love vs. Beethoven 5th Symphony [OFFICIAL VIDEO]
2CELLOS - Smooth Criminal (Live at Suntory Hall, Tokyo)
2CELLOS - Smells Like Teen Spirit [Live at Sydney Opera House]
2CELLOS - Despacito [OFFICIAL VIDEO]
13 Year Old Girl Playing Il Silenzio (The Silence) - André Rieu
094.All About That Bass
00 - SADNESS PART 1
(Ghost) Riders In the Sky (American Outlaws Live at Nassau Coliseum, 1
(Everything I Do) I Do It For You - Bryan Adams (Boyce Avenue ft. Conn
What a wonderful world
Moon river
×