The Duke of York said in a BBC interview in November that he did not see, or suspect, any suspicious behaviour when visiting the homes of his then friend.
If it happens, it is all some way off in the future. Statements by US prosecutor Geoffrey Berman and lawyers for Epstein's accusers are putting moral pressure on Prince Andrew to co-operate.
That co-operation could be provided by the prince informally by agreement. This is something that his lawyers are likely to be seriously considering now.
It is significant that neither US prosecutors nor lawyers for Epstein's accusers have yet issued MLA requests, so there is the opportunity for the prince to co-operate informally.
A subpoena is an order to compel someone to appear in court or to submit evidence.
If that happens, there is no obligation for Prince Andrew to go to the US and submit to the subpoena.
If he did travel to the US and there is an outstanding subpoena, he could in theory be arrested for contempt of court and taken to a court to answer questions.
It is obviously highly unlikely that he would be arrested. It would be more likely that he would simply be required to go to court and answer questions. Once in court the Prince could exercise his right against self-incrimination and refuse to answer questions.
Daniel Sternberg, a barrister specialising in extradition law at Temple Garden Chambers in London, said: "It is important to remember that Prince Andrew has not been charged with any offence in the US. The FBI is investigating whether he has material evidence that could assist in its criminal investigation of alleged sex trafficking.
"In the civil case brought by Epstein's victims, the close friendship between the Prince and Epstein means that the lawyers for Epstein's victims believe his evidence may be relevant to their claims.
"While there is no way to compel Prince Andrew to give evidence in the UK or the US in either the civil or criminal case, his failure to do so does not sit well with his previous public statements that he would help any appropriate law enforcement agency with its inquiries."
However the legal process develops, Prince Andrew's discomfort is likely to increase.
Until justice is blind to color, until education is unaware of race, until opportunity is unconcerned with the color of men's skins, emancipation will be a proclamation but not a fact.