Melvin Cook has advanced brain disease meaning any infection could kill him.
He and wife Dorothy have been shielding since the start of the Covid-19 pandemic, but a recent fall has meant Mr Cook needs carers at their Bristol home.
There is currently no legal requirement for health workers to be vaccinated.
Mrs Cook said that since the start of the pandemic, their home in Knowle has been effectively sealed off.
"I wouldn't touch the post, I would leave it for 72 hours," she said.
"We literally closed the door up and nobody was allowed in, not even our family."
But Mr Cook had a fall in February and needed hospital treatment. When he came home, a critical care team was put in place to look after him.
"We had to make a really hard choice. Do we not have the carers in and protect ourselves from Covid, or do we have the carers in because he was seriously ill?"
Mr Cook is currently in a specialist rehab unit and his wife is pushing for vaccinations to be mandatory for all frontline staff.
"If you choose to be a frontline worker, any frontline position, I think it's absolutely essential that you have a vaccination," she added.
David Smallacombe, chief executive officer at Care & Support West, which is not the Cook's care provider, said deciding whether or not to have the vaccination was a "very personal matter" and there were "lots of reasons" why people might be hesitant.
"As an organisation we don't have a position that says you must have a jab in order to work in social care," he said.
"It is possible that might become a mandatory position from central government, at which point things will change."
I knew that if I failed I wouldn’t regret that, but I knew the one thing I might regret is not trying.