London Daily

Focus on the big picture.
Thursday, Jul 10, 2025

Japanese researchers create a 'vaccine' against getting old

Japanese researchers create a 'vaccine' against getting old

Researchers at a Tokyo university say their vaccine slowed the ageing process in mice, and could even aid the treatment of ageing-related diseases.

What if you could live forever? It's a question long pondered by fictional supervillains and Silicon Valley billionaires alike.

Now researchers in Japan say they may have taken a step toward boosting human longevity with successful trials of a vaccine against the cells that contribute to the ageing process.

In laboratory trials, a drug targeting a protein contained in senescent cells - those which have naturally stopped reproducing themselves - slowed the progression of frailty in older mice, the researchers from Tokyo's Juntendo University said.

The vaccine also successfully targeted the senescent cells in fatty tissue and blood vessels, suggesting it could have a positive impact on other medical conditions linked to ageing.

"We can expect that (the vaccine) will be applied to the treatment of arterial stiffening, diabetes and other ageing-related diseases," Juntendo professor Toru Minamino told Japan's Jiji news agency.

What is cellular senescence?


Cells become senescent when they stop duplicating themselves, often in response to naturally-occurring damage to their DNA. Cellular senescence is thought to contribute to the ageing process itself, as well as ageing-related diseases like Alzheimer's and some cancers.

"Senescent cells secrete a series of factors that disrupt the function of the tissue," Dr Salvador Macip, head of the University of Leicester's Mechanisms of Cancer and Ageing Lab, told Euronews Next.

"They 'call' cells from the immune system, in theory to be cleared by them (but that eventually fails) and create a chronic low level inflammation, mixed with fibrosis," Macip said.

Macip was part of an international team of academics from universities in the UK, Spain, Nigeria and Saudi Arabia that published research on another method of tackling senescent cells in October this year.

"The biological process of ageing is very complex, therefore it is unlikely that one single strategy will completely stop it or reverse it. However, there are probably many ways to slow it down, and clearing senescent cells seems to be one of the easiest and potentially more effective," he said.

The limit on lifespan


In laboratory tests, preventing the build-up of senescent cells extended the lifespan of mice by 15 per cent, Macip told Euronews Next. Other, similar experiments have achieved as much as a 35 per cent increase, he said.

File photo. Similar experiments have reported up to a 35 per cent increase in the longevity of mice, Macip said


But before you get too excited, it's worth bearing in mind that researchers still don't know how much a living creature's lifespan can be extended.

"This is a very interesting question, and one that we still have not agreed upon. Some believe there is a 'hard' limit for human lifespan (around 130 years is the current estimate), while others think that, on paper, immortality should be feasible," Macip said.

"It's still early to know how much life can be extended and whether there's a limit or not".

We may not have to wait too long for an answer, though.

"The field of anti-ageing research is advancing very fast. In the last decade, there have been many key discoveries," Macip said.

"The person that will take the first anti-ageing pill has probably already been born".

Newsletter

Related Articles

0:00
0:00
Close
Severe Heatwave Claims 2,300 Lives Across Europe
NVIDIA Achieves Historic Milestone as First Company Valued at $4 Trillion
Declining Beer Consumption Signals Cultural Shift in Germany
Linda Yaccarino Steps Down as CEO of X After Two Years
US Imposes New Tariffs on Brazilian Exports Amid Political Tensions
Azerbaijan and Armenia are on the brink of a historic peace deal.
Emails Leaked: How Passenger Luggage Became a Side Income for Airport Workers
Polish MEP: “Dear Leftists - China is laughing at you, Russia is laughing, India is laughing”
BRICS Expands Membership with Indonesia and Ten New Partner Countries
Weinstein Victim’s Lawyer Says MeToo Movement Still Strong
U.S. Enacts Sweeping Tax and Spending Legislation Amid Trade Policy Shifts
Football Mourns as Diogo Jota and Brother André Silva Laid to Rest in Portugal
Labour Expected to Withdraw Support for Special Needs Funding Model
Leaked Audio Reveals Tory Aide Defending DEI Record
Elon Musk Founds a Party Following a Poll on X: "You Wanted It – You Got It!"
London Stock Exchange Faces Historic Low in Initial Public Offerings
A new online platform has emerged in the United Kingdom, specifically targeting Muslim men seeking virgin brides
Trump Celebrates Independence Day with B-2 Flyover and Signs Controversial Legislation
Boris Johnson Urges Conservatives to Ignore Farage
SNP Ordered to Update Single-Sex Space Guidance Within Days
Starmer Set to Reject Calls for Wealth Taxes
Stolen Century-Old Rolls-Royce Recovered After Hotel Theft
Macron Presses Starmer to Recognise Palestinian State
Labour Delayed Palestine Action Ban Over Riot Concerns
Swinney’s Tax Comments ‘Offensive to Scots’, Say Tories
High Street Retailers to Enforce Bans on Serial Shoplifters
Music Banned by Henry VIII to Be Performed After 500 Years
Steve Coogan Says Working Class Is Being ‘Ethnically Cleansed’
Home Office Admits Uncertainty Over Visa Overstayer Numbers
JD Vance Questions Mandelson Over Reform Party’s Rising Popularity
Macron to Receive Windsor Carriage Ride in Royal Gesture
Labour Accused of ‘Hammering’ Scots During First Year in Power
BBC Head of Music Stood Down Amid Bob Vylan Controversy
Corbyn Eyes Hard-Left Challenge to Starmer’s Leadership
London Tube Trains Suspended After Major Fire Erupts Nearby
Richard Kemp: I Felt Safer in Israel Under Attack Than in the UK
Cyclist Says Police Cited Human Rights Act for Riding No-Handed
China’s Central Bank Consults European Peers on Low-Rate Strategies
AI Raises Alarms Over Long-Term Job Security
Saudi Arabia Maintains Ties with Iran Despite Israel Conflict
Musk Battles to Protect Tesla Amid Trump Policy Threats
Air France-KLM Acquires Majority Stake in Scandinavian Airlines
UK Educators Sound Alarm on Declining Child Literacy
Shein Fined €40 Million in France Over Misleading Discounts
Brazil’s Lula Visits Kirchner During Argentina House Arrest
Trump Scores Legislative Win as House Passes Tax Reform Bill
Keir Starmer Faces Criticism After Rocky First Year in Power
DJI Launches Heavy-Duty Coaxial Quadcopter with 80 kg Lift Capacity
U.S. Senate Approves Major Legislation Dubbed the 'Big Beautiful Bill'
Largest Healthcare Fraud Takedown in U.S. History Announced by DOJ
×