London Daily

Focus on the big picture.
Thursday, Jul 24, 2025

Vaccine Mix-And-Match Approach Bolsters Antibodies, Says Study

Vaccine Mix-And-Match Approach Bolsters Antibodies, Says Study

The US government-sponsored trial is the first major US study to compare the effects of using different vaccines as boosters from the initial shot or shots.
Mixing Covid vaccines produces as much or more antibodies as using the same shot as a booster, according to preliminary results of a widely awaited US government-sponsored trial.

The trial is the first major US study to compare the effects of using different vaccines as boosters from the initial shot or shots. The complicated, 9-arm trial involved over 450 people and measured the effects from giving a booster shot of the Moderna Inc, Pfizer Inc.-BioNTech SE or Johnson & Johnson vaccines to those who had originally gotten a different vaccine.

Overall, the results found that mixing-and-matching resulted in comparable or higher levels of neutralizing antibodies compared to same-vaccine boosting, the researchers said in the preprint posted on medRxiv.org. Rates of adverse events were similar across all the different booster groups, the study found.

"These data suggest that if a vaccine is approved or authorized as a booster, an immune response will be generated regardless of the primary Covid-19 vaccination regimen," the researchers said in their conclusion.

The results from the ongoing trial have not yet been peer reviewed and published in a medical journal. More detail about the study is expected to be disclosed Friday afternoon at a meeting of FDA advisory panel, where researchers conducting the trial are scheduled to give a presentation on their early findings.

Mixing and matching boosters has become an increasingly important issue. Many countries outside the US have used the method for in an attempt to maximize vaccine effectiveness or avoid rare side effects that have been associated with some shots.

In the US, some people who received the Johnson & Johnson shot may be interested in getting a messenger RNA shot as a booster. Also, mixing-and-matching could make it easier for officials to roll out boosters more broadly, as people getting boosters could receive any Covid vaccine on hand at their pharmacy and wouldn't have to seek out the specific shot they had gotten previously.

Outside the US, concerns about rare blood clots associated with AstraZeneca Plc's vaccine led to many countries in Europe to pause use of the shot and instead administer a different second dose. In the UK health authorities have rolled out a booster program for an extra dose of the Pfizer vaccine as the preferred option, and also offered a half dose of the Moderna shot as an alternative.
Comments

Oh ya 4 year ago
And if the 3rd does not get you soon there will be 4th,5th,19th until the spike proteins are running out your ears

Newsletter

Related Articles

0:00
0:00
Close
Thai Civilian Death Toll Rises to 12 in Cambodian Cross-Border Attacks
TSUNAMI: Trump Just Crossed the Rubicon—And There’s No Turning Back
Over 120 Criminal Cases Dismissed in Boston Amid Public Defender Shortage
UN's Top Court Declares Environmental Protection a Legal Obligation Under International Law
"Crazy Thing": OpenAI's Sam Altman Warns Of AI Voice Fraud Crisis In Banking
The Podcaster Who Accidentally Revealed He Earns Over $10 Million a Year
Trump Announces $550 Billion Japanese Investment and New Trade Agreements with Indonesia and the Philippines
US Treasury Secretary Calls for Institutional Review of Federal Reserve Amid AI‑Driven Growth Expectations
UK Government Considers Dropping Demand for Apple Encryption Backdoor
Severe Flooding in South Korea Claims Lives Amid Ongoing Rescue Operations
Japanese Man Discovers Family Connection Through DNA Testing After Decades of Separation
Russia Signals Openness to Ukraine Peace Talks Amid Escalating Drone Warfare
Switzerland Implements Ban on Mammography Screening
Japanese Prime Minister Vows to Stay After Coalition Loses Upper House Majority
Pogacar Extends Dominance with Stage Fifteen Triumph at Tour de France
CEO Resigns Amid Controversy Over Relationship with HR Executive
Man Dies After Being Pulled Into MRI Machine Due to Metal Chain in New York Clinic
NVIDIA Achieves $4 Trillion Valuation Amid AI Demand
US Revokes Visas of Brazilian Corrupted Judges Amid Fake Bolsonaro Investigation
U.S. Congress Approves Rescissions Act Cutting Federal Funding for NPR and PBS
North Korea Restricts Foreign Tourist Access to New Seaside Resort
Brazil's Supreme Court Imposes Radical Restrictions on Former President Bolsonaro
Centrist Criticism of von der Leyen Resurfaces as she Survives EU Confidence Vote
Judge Criticizes DOJ Over Secrecy in Dropping Charges Against Gang Leader
Apple Closes $16.5 Billion Tax Dispute With Ireland
Von der Leyen Faces Setback Over €2 Trillion EU Budget Proposal
UK and Germany Collaborate on Global Military Equipment Sales
Trump Plans Over 10% Tariffs on African and Caribbean Nations
Flying Taxi CEO Reclaims Billionaire Status After Stock Surge
Epstein Files Deepen Republican Party Divide
Zuckerberg Faces $8 Billion Privacy Lawsuit From Meta Shareholders
FIFA Pressured to Rethink World Cup Calendar Due to Climate Change
SpaceX Nears $400 Billion Valuation With New Share Sale
Microsoft, US Lab to Use AI for Faster Nuclear Plant Licensing
Trump Walks Back Talk of Firing Fed Chair Jerome Powell
Zelensky Reshuffles Cabinet to Win Support at Home and in Washington
"Can You Hit Moscow?" Trump Asked Zelensky To Make Putin "Feel The Pain"
Irish Tech Worker Detained 100 days by US Authorities for Overstaying Visa
Dimon Warns on Fed Independence as Trump Administration Eyes Powell’s Succession
Church of England Removes 1991 Sexuality Guidelines from Clergy Selection
Superman Franchise Achieves Success with Latest Release
Hungary's Viktor Orban Rejects Agreements on Illegal Migration
Jeff Bezos Considers Purchasing Condé Nast as a Wedding Gift
Ghislaine Maxwell Says She’s Ready to Testify Before Congress on Epstein’s Criminal Empire
Bal des Pompiers: A Celebration of Community and Firefighter Culture in France
FBI Chief Kash Patel Denies Resignation Speculations Amid Epstein List Controversy
Air India Pilot’s Mental Health Records Under Scrutiny
Google Secures Windsurf AI Coding Team in $2.4 Billion Licence Deal
Jamie Dimon Warns Europe Is Losing Global Competitiveness and Flags Market Complacency
South African Police Minister Suspended Amid Organised Crime Allegations
×