Squatters have occupied Gordon Ramsay's £13m London pub, the York & Albany hotel and gastropub near Regent's Park.
They have boarded up windows and posted a "legal warning" defending their occupation.
The group intends to use the space as a community art cafe.
Gordon Ramsay Restaurants has been contacted for comment, but no response has been given yet.
The BBC reports that a notice asking for food and donations had been removed by the squatters.
Two Instagram accounts, Camden Art Cafe and Autonomous Winter Shelter, have shared photos of a "new squatted community space" at the York & Albany hotel.
The Metropolitan Police were informed but considered it a "civil matter." Photos show the interior of the pub with tables set up, and before further boarding up, a squatter was seen sleeping in the bar surrounded by litter.
On Saturday, two masked squatters exited the property, evading journalists.
The Met did not intervene.
A group of people, identified as "The Occupiers," posted a notice on a door stating they had the right to occupy the venue.
They argued that the building was not a "residential building" and thus exempt from the 2012 legislation banning squatting in residential properties.
The notice was signed by the occupiers and warned that unauthorized entry without their permission could lead to criminal consequences such as prison sentences or fines.
The group stated that to evict them, legal action would need to be taken through the county or high court.