Thousands of festival-goers have descended upon the grounds in Pilton, Somerset.
The music bill includes Sir Elton John, Lana Del Rey, Lewis Capaldi, and Lil Nas X.
Ms. Eavis aimed for gender balance in the line-up, but a female headline act dropped out.
The weather forecast includes a yellow thunderstorm warning until 19:00, with a 75% risk of rain.
Festival-goers have arrived as early as 01:30 BST to secure their spot.
Some have been at the front of the queue since Wednesday.
The festival has a history of environmental friendliness, and organizers have pushed for this ethos even more this year.
Glastonbury festivalgoers have arrived at the site, with some reporting that the spirit of the festival is "free and unpredictable." Friday's main stage features a mystery band listed as "The Churnups" before Arctic Monkeys and rock duo Royal Blood, with rumors of a possible appearance by the rock band Foo Fighters.
Yusuf, also known as Cat Stevens, will play the legend slot on Sunday afternoon, following in the footsteps of artists such as Dolly Parton, Kylie Minogue, and Diana Ross.
Organizers have warned against bringing disposable vapes, as well as other items such as gazebos, non-biodegradable body glitter, disposable wipes, knives, and anything made of glass, as they can pollute the environment and be hazardous at waste centers.
LONDON DAILY ARCHIVE
Glastonbury Festival Kicks Off with Thousands in Attendance Despite Cancelled Headline Act
The 38th Glastonbury Festival has officially begun with the opening of the gates by co-organizer Emily Eavis.
21 June 2023 · 19:33 UTC
